Jennifer S Kim1, Scott Sicherer. 1. Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, New York 10029-6574, USA. jennifer.kim@mssm.edu
Abstract
PURPOSE OF REVIEW: To discuss whether strict allergen avoidance is the most appropriate strategy for managing or preventing food allergy. RECENT FINDINGS: The standard of care for the management of food allergy has been strict allergen avoidance. This advice is based upon the suppositions that exposure could result in allergic reactions and avoidance may speed recovery. Recent studies challenge these assumptions. Studies now demonstrate that most children with milk and egg allergy tolerate extensively heated forms of these foods. Moreover, clinical trials of oral immunotherapy show that oral exposure can lead to desensitization. Additionally, recent epidemiologic studies fail to support the notion that delaying introduction of highly allergenic foods to infants and young children prevents the development of food allergy. In fact, the data suggest that delays may increase risks. SUMMARY: Recent data indicate that strict allergen avoidance is not always necessary for treatment, exposure may be therapeutic, and extended delay in introduction of food allergens to the diet of young children may increase allergy risks. However, in many circumstances strict avoidance is clearly necessary for treatment. Additional studies are needed to determine the risks and benefits of exposure to tolerated allergen, including identification of biomarkers to identify patients who may benefit.
PURPOSE OF REVIEW: To discuss whether strict allergen avoidance is the most appropriate strategy for managing or preventing food allergy. RECENT FINDINGS: The standard of care for the management of food allergy has been strict allergen avoidance. This advice is based upon the suppositions that exposure could result in allergic reactions and avoidance may speed recovery. Recent studies challenge these assumptions. Studies now demonstrate that most children with milk and egg allergy tolerate extensively heated forms of these foods. Moreover, clinical trials of oral immunotherapy show that oral exposure can lead to desensitization. Additionally, recent epidemiologic studies fail to support the notion that delaying introduction of highly allergenic foods to infants and young children prevents the development of food allergy. In fact, the data suggest that delays may increase risks. SUMMARY: Recent data indicate that strict allergen avoidance is not always necessary for treatment, exposure may be therapeutic, and extended delay in introduction of food allergens to the diet of young children may increase allergy risks. However, in many circumstances strict avoidance is clearly necessary for treatment. Additional studies are needed to determine the risks and benefits of exposure to tolerated allergen, including identification of biomarkers to identify patients who may benefit.
Authors: Jennifer S Kim; Anna Nowak-Węgrzyn; Scott H Sicherer; Sally Noone; Erin L Moshier; Hugh A Sampson Journal: J Allergy Clin Immunol Date: 2011-05-23 Impact factor: 10.793