INTRODUCTION: The purpose of the study is to determine if functional status and quality of life (QoL) vary with glomerular filtration rate (GFR) among older adults. METHODS: We studied adults aged 45 years and older participating in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study. Data included demographic and health information, serum creatinine and hemoglobin, the 4-item Center for Epidemiologic Studies Depression Scale (CES-D-4), the 4-item Cohen's Perceived Stress Scale (PSS-4), reported health status and inactivity and the Medical Outcomes Study Short Form-12 (SF-12) QoL scores. RESULTS: CKD (GFR <60 ml/min/1.73 m(2)) was present in 11.6% of the subjects. As GFR declined, the SF-12 physical component score, adjusted for other participant attributes, declined from 38.9 to 35.9 (p = 0.0001). After adjustment for other risk factors, poorer personal health scores (p < 0.0001) and decreased physical activity (p < 0.0001) were reported as GFR declined. In contrast, after adjusting for other participant characteristics, depression scores and stress scores and the mental component score of the SF-12 were not associated with kidney function. CONCLUSION: Older individuals with CKD in the US population experience an increased prevalence of impaired QoL that cannot be fully explained by other individual characteristics. 2010 S. Karger AG, Basel.
INTRODUCTION: The purpose of the study is to determine if functional status and quality of life (QoL) vary with glomerular filtration rate (GFR) among older adults. METHODS: We studied adults aged 45 years and older participating in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study. Data included demographic and health information, serum creatinine and hemoglobin, the 4-item Center for Epidemiologic Studies Depression Scale (CES-D-4), the 4-item Cohen's Perceived Stress Scale (PSS-4), reported health status and inactivity and the Medical Outcomes Study Short Form-12 (SF-12) QoL scores. RESULTS:CKD (GFR <60 ml/min/1.73 m(2)) was present in 11.6% of the subjects. As GFR declined, the SF-12 physical component score, adjusted for other participant attributes, declined from 38.9 to 35.9 (p = 0.0001). After adjustment for other risk factors, poorer personal health scores (p < 0.0001) and decreased physical activity (p < 0.0001) were reported as GFR declined. In contrast, after adjusting for other participant characteristics, depression scores and stress scores and the mental component score of the SF-12 were not associated with kidney function. CONCLUSION: Older individuals with CKD in the US population experience an increased prevalence of impaired QoL that cannot be fully explained by other individual characteristics. 2010 S. Karger AG, Basel.
Authors: Virginia J Howard; Mary Cushman; Leavonne Pulley; Camilo R Gomez; Rodney C Go; Ronald J Prineas; Andra Graham; Claudia S Moy; George Howard Journal: Neuroepidemiology Date: 2005-06-29 Impact factor: 3.282
Authors: Rachel L Perlman; Fredric O Finkelstein; Lei Liu; Erik Roys; Margaret Kiser; George Eisele; Sally Burrows-Hudson; Joseph M Messana; Nathan Levin; Sanjay Rajagopalan; Friedrich K Port; Robert A Wolfe; Rajiv Saran Journal: Am J Kidney Dis Date: 2005-04 Impact factor: 8.860
Authors: Irina Gorodetskaya; Stefanos Zenios; Charles E McCulloch; Alan Bostrom; Chi-Yuan Hsu; Andrew B Bindman; Alan S Go; Glenn M Chertow Journal: Kidney Int Date: 2005-12 Impact factor: 10.612
Authors: Faisal M Shuaib; Raegan W Durant; Gaurav Parmar; Todd M Brown; David L Roth; Martha Hovater; Jewell H Halanych; James M Shikany; George Howard; Monika M Safford Journal: J Health Care Poor Underserved Date: 2012-05
Authors: Jenna M Norton; Marva M Moxey-Mims; Paul W Eggers; Andrew S Narva; Robert A Star; Paul L Kimmel; Griffin P Rodgers Journal: J Am Soc Nephrol Date: 2016-05-13 Impact factor: 10.121
Authors: Sarah J Ramer; Natalie N McCall; Cassianne Robinson-Cohen; Edward D Siew; Huzaifah Salat; Aihua Bian; Thomas G Stewart; Maie H El-Sourady; Mohana Karlekar; Loren Lipworth; T Alp Ikizler; Khaled Abdel-Kader Journal: J Am Soc Nephrol Date: 2018-11-01 Impact factor: 10.121
Authors: Grace J Wang; Pamela A Shaw; Raymond R Townsend; Amanda H Anderson; Dawei Xie; Xue Wang; Lisa C Nessel; Emile R Mohler; Stephen M Sozio; Bernard G Jaar; Jing Chen; Jackson Wright; Jonathan J Taliercio; Akinlolu Ojo; Ana C Ricardo; Eva Lustigova; Ronald M Fairman; Harold I Feldman; Bonnie Ky Journal: Ann Vasc Surg Date: 2016-05-20 Impact factor: 1.466
Authors: Claire Juliet Martin; Elmi Muller; Demetre Labadarios; Frederick Johannes Veldman; Susanna Maria Kassier Journal: Qual Life Res Date: 2021-06-22 Impact factor: 4.147