Literature DB >> 20164590

Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.

Michelle T Fodero-Tavoletti1, Victor L Villemagne, Brett M Paterson, Anthony R White, Qiao-Xin Li, James Camakaris, Graeme O'Keefe, Roberto Cappai, Kevin J Barnham, Paul S Donnelly.   

Abstract

A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.

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Year:  2010        PMID： 20164590     DOI： 10.3233/JAD-2010-1359

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  22 in total

1.  A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model.

Authors:  Emily L Que; Elizabeth J New; Christopher J Chang
Journal:  Chem Sci       Date:  2012-04-18       Impact factor: 9.825

2.  Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer's disease.

Authors:  Hong-Jun Cho; Truc T Huynh; Buck E Rogers; Liviu M Mirica
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-24       Impact factor: 11.205

3.  Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.

Authors:  Cynthia P W Soon; Paul S Donnelly; Bradley J Turner; Lin W Hung; Peter J Crouch; Nicki A Sherratt; Jiang-Li Tan; Nastasia K-H Lim; Linh Lam; Laura Bica; SinChun Lim; James L Hickey; Julia Morizzi; Andrew Powell; David I Finkelstein; Janetta G Culvenor; Colin L Masters; James Duce; Anthony R White; Kevin J Barnham; Qiao-Xin Li
Journal:  J Biol Chem       Date:  2011-10-27       Impact factor: 5.157

Review 4.  Alzheimer's disease & metals: therapeutic opportunities.

Authors:  Vijaya B Kenche; Kevin J Barnham
Journal:  Br J Pharmacol       Date:  2011-05       Impact factor: 8.739

5.  Studies of copper trafficking in a mouse model of Alzheimer's disease by positron emission tomography: comparison of 64Cu acetate and 64CuGTSM.

Authors:  Erica M Andreozzi; Julia Baguña Torres; Kavitha Sunassee; Joel Dunn; Simon Walker-Samuel; Istvan Szanda; Philip J Blower
Journal:  Metallomics       Date:  2017-11-15       Impact factor: 4.526

Review 6.  Radiopharmaceuticals for Assessment of Altered Metabolism and Biometal Fluxes in Brain Aging and Alzheimer's Disease with Positron Emission Tomography.

Authors:  Fang Xie; Fangyu Peng
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

Review 7.  Metal imaging in neurodegenerative diseases.

Authors:  Megan W Bourassa; Lisa M Miller
Journal:  Metallomics       Date:  2012-07-16       Impact factor: 4.526

Review 8.  A nuclear chocolate box: the periodic table of nuclear medicine.

Authors:  Philip J Blower
Journal:  Dalton Trans       Date:  2015-03-21       Impact factor: 4.390

9.  The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease.

Authors:  Lin W Hung; Victor L Villemagne; Lesley Cheng; Nicki A Sherratt; Scott Ayton; Anthony R White; Peter J Crouch; SinChun Lim; Su Ling Leong; Simon Wilkins; Jessica George; Blaine R Roberts; Chi L L Pham; Xiang Liu; Francis C K Chiu; David M Shackleford; Andrew K Powell; Colin L Masters; Ashley I Bush; Graeme O'Keefe; Janetta G Culvenor; Roberto Cappai; Robert A Cherny; Paul S Donnelly; Andrew F Hill; David I Finkelstein; Kevin J Barnham
Journal:  J Exp Med       Date:  2012-04-02       Impact factor: 14.307

10.  PET Imaging of Copper Trafficking in a Mouse Model of Alzheimer Disease.

Authors:  Julia Baguña Torres; Erica M Andreozzi; Joel T Dunn; Muhammad Siddique; Istvan Szanda; David R Howlett; Kavitha Sunassee; Philip J Blower
Journal:  J Nucl Med       Date:  2015-10-08       Impact factor: 10.057
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