Literature DB >> 2016385

Determination of beta-carbolines in foodstuffs by high-performance liquid chromatography and high-performance liquid chromatography-mass spectrometry.

J Adachi1, Y Mizoi, T Naito, K Yamamoto, S Fujiwara, I Ninomiya.   

Abstract

A high-performance liquid chromatographic method combined with fluorimetric detection is described for the determination of beta-carboline (norharman) and 1-methyl-beta-carboline (harman). The analysis of foodstuffs for the identification of beta-carbolines is facilitated by clean-up samples using Bond Elut PRS cartridges. Recoveries were excellent. Further, a high-performance liquid chromatographic-mass spectrometric method was also developed for their identification. The concentration of beta-carboline among the foodstuffs and alcoholic beverages varied greatly. Also, norharman and harman were observed in uncooked foodstuffs, whereas acetaldehyde was found in most fermented food. The toxicological implication of beta-carbolines in foodstuffs is discussed.

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Year:  1991        PMID： 2016385     DOI： 10.1016/s0021-9673(01)88854-3

Source DB:  PubMed          Journal:  J Chromatogr


  6 in total

1.  Determination of harmane and harmine in human blood using reversed-phased high-performance liquid chromatography and fluorescence detection.

Authors:  W Zheng; S Wang; L F Barnes; Y Guan; E D Louis
Journal:  Anal Biochem       Date:  2000-03-15       Impact factor: 3.365

2.  Characterization of brain beta-carboline-2-N-methyltransferase, an enzyme that may play a role in idiopathic Parkinson's disease.

Authors:  D A Gearhart; E J Neafsey; M A Collins
Journal:  Neurochem Res       Date:  1997-02       Impact factor: 3.996

3.  Toxicokinetics of tremorogenic natural products, harmane and harmine, in male Sprague-Dawley rats.

Authors:  Y Guan; E D Louis; W Zheng
Journal:  J Toxicol Environ Health A       Date:  2001-12-21

4.  Comparison of the in vitro binding characteristics of the beta-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla.

Authors:  T May; A Greube; S Strauss; D Heineke; J Lehmann; H Rommelspacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-03       Impact factor: 3.000

5.  Elevation of blood beta-carboline alkaloids in essential tremor.

Authors:  E D Louis; W Zheng; E C Jurewicz; D Watner; J Chen; P Factor-Litvak; M Parides
Journal:  Neurology       Date:  2002-12-24       Impact factor: 9.910

6.  β-Carbolines in Experiments on Laboratory Animals.

Authors:  Renata Zawirska-Wojtasiak; Agnieszka Fedoruk-Wyszomirska; Paulina Piechowska; Sylwia Mildner-Szkudlarz; Joanna Bajerska; Elżbieta Wojtowicz; Krzysztof Przygoński; Dorota Gurda; Wiktoria Kubicka; Eliza Wyszko
Journal:  Int J Mol Sci       Date:  2020-07-24       Impact factor: 5.923
  6 in total

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