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Literature DB >> 20163792

Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens.

Patricia R Taylor¹, Christopher C Paustian, Gary K Koski, Daniel H Zimmerman, Ken S Rosenthal.

Abstract

LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide containing a major histocompatibility antigen binding peptide conjugated to an immune cell binding ligand (ICBL) such as the 'J' peptide from beta-2-microglobulin. Treatment of monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD (containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing dendritic cells. JgD-dendritic cells supported allotypic activation of T cells to produce Th1-related cytokines. Copyright 2010 Elsevier Inc. All rights reserved.

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Year: 2010 PMID： 20163792 PMCID： PMC4481128 DOI： 10.1016/j.cellimm.2010.01.003

Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868

19 in total

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