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Literature DB >> 2016352

Hyperthermia-induced neuronal protection against ischemic injury in gerbils.

K Kitagawa¹, M Matsumoto, M Tagaya, K Kuwabara, R Hata, N Handa, R Fukunaga, K Kimura, T Kamada.

Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

Entities: Disease Gene

Mesh：

Year: 1991 PMID： 2016352 DOI： 10.1038/jcbfm.1991.86

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

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Cited

9 in total

Review 1. Heat shock proteins in brain ischemia: role undefined as yet.

Authors: K Kumar
Journal: Metab Brain Dis Date: 1992-09 Impact factor: 3.584

2. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid.

Authors: J J Yan; J Y Cho; H S Kim; K L Kim; J S Jung; S O Huh; H W Suh; Y H Kim; D K Song
Journal: Br J Pharmacol Date: 2001-05 Impact factor: 8.739

3. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein.

Authors: Y Tsukamoto; K Kuwabara; S Hirota; J Ikeda; D Stern; H Yanagi; M Matsumoto; S Ogawa; Y Kitamura
Journal: J Clin Invest Date: 1996-10-15 Impact factor: 14.808

Hyperthermia-induced neuronal protection against ischemic injury in gerbils.

Review 1. Heat shock proteins in brain ischemia: role undefined as yet.

2. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid.

3. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein.

4. NMDA receptor antagonism does not inhibit induction of ischemic tolerance in gerbil brain in vivo.

5. Activation of the nuclear factor-kappaB is a key event in brain tolerance.

6. Seizure preconditioning and epileptic tolerance: models and mechanisms.

7. Recovery of protein synthesis in tolerance-induced hippocampal CA1 neurons after transient forebrain ischemia.

8. Thermal Injury Induces Small Heat Shock Protein in the Optic Nerve Head In Vivo.

Review 9. Nanotechnology for Medical and Surgical Glaucoma Therapy-A Review.