Literature DB >> 20162159

Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers.

Cristian Samorì1, Hanene Ali-Boucetta, Raquel Sainz, Chang Guo, Francesca Maria Toma, Chiara Fabbro, Tatiana da Ros, Maurizio Prato, Kostas Kostarelos, Alberto Bianco.   

Abstract

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

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Year:  2009        PMID： 20162159     DOI： 10.1039/b923560d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors.

Authors:  Yucai Wang; Jinbin Xu; Xiaohu Xia; Miaoxin Yang; Suwanna Vangveravong; Jingyi Chen; Robert H Mach; Younan Xia
Journal:  Nanoscale       Date:  2011-11-24       Impact factor: 7.790

2.  Carbon nanotubes linked with pitavastatin: synthesis and characterisation.

Authors:  E Borowiak-Palen; P Skupin; M Kruszynska; L Sobotta; J Mielcarek
Journal:  J Mater Sci Mater Med       Date:  2011-03-01       Impact factor: 3.896

Review 3.  Breast cancer: insights in disease and influence of drug methotrexate.

Authors:  Vítor Yang; Maria João Gouveia; Joana Santos; Beate Koksch; Irina Amorim; Fátima Gärtner; Nuno Vale
Journal:  RSC Med Chem       Date:  2020-05-28

Review 4.  A new era of cancer treatment: carbon nanotubes as drug delivery tools.

Authors:  Seyed Yazdan Madani; Naghmeh Naderi; Oshani Dissanayake; Aaron Tan; Alexander M Seifalian
Journal:  Int J Nanomedicine       Date:  2011-11-22

5.  Validation of a Janus role of methotrexate-based PEGylated chitosan nanoparticles in vitro.

Authors:  Fanghong Luo; Yang Li; Mengmeng Jia; Fei Cui; Hongjie Wu; Fei Yu; Jinyan Lin; Xiangrui Yang; Zhenqing Hou; Qiqing Zhang
Journal:  Nanoscale Res Lett       Date:  2014-07-23       Impact factor: 4.703

Review 6.  Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors.

Authors:  Fakhar Ud Din; Waqar Aman; Izhar Ullah; Omer Salman Qureshi; Omer Mustapha; Shumaila Shafique; Alam Zeb
Journal:  Int J Nanomedicine       Date:  2017-10-05

Review 7.  Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment.

Authors:  Manuela Curcio; Annafranca Farfalla; Federica Saletta; Emanuele Valli; Elvira Pantuso; Fiore Pasquale Nicoletta; Francesca Iemma; Orazio Vittorio; Giuseppe Cirillo
Journal:  Molecules       Date:  2020-04-30       Impact factor: 4.411

Review 8.  Pharmaceutical and biomedical applications of surface engineered carbon nanotubes.

Authors:  Neelesh Kumar Mehra; Keerti Jain; Narendra Kumar Jain
Journal:  Drug Discov Today       Date:  2015-01-17       Impact factor: 7.851

9.  Cationic Liposome- Multi-Walled Carbon Nanotubes Hybrids for Dual siPLK1 and Doxorubicin Delivery In Vitro.

Authors:  Sara Pereira; Jin Lee; Noelia Rubio; Hatem A F M Hassan; Izzat Bin Mohamed Suffian; Julie T W Wang; Rebecca Klippstein; Belén Ballesteros; Wafa' T Al-Jamal; Khuloud T Al-Jamal
Journal:  Pharm Res       Date:  2015-06-18       Impact factor: 4.200

10.  Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells.

Authors:  Giuseppe Cirillo; Orazio Vittorio; David Kunhardt; Emanuele Valli; Florida Voli; Annafranca Farfalla; Manuela Curcio; Umile Gianfranco Spizzirri; Silke Hampel
Journal:  Materials (Basel)       Date:  2019-09-06       Impact factor: 3.623
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