Literature DB >> 20162096

Anticonvulsant activity of Diospyros fischeri root extracts.

Mainen J Moshi1, Zakaria H Mbwambo, Ramadhani S O Nondo, Pax J Masimba, Modest C Kapingu, Edward S Magelewanya.   

Abstract

Diospyros fischeri Gurke (Ebenaceae) is used in traditional medicine for the treatment of epilepsy. Dichloromethane, ethylacetate, and ethanol extracts of the roots, at doses between 100 and 1600 mg/kg BW, inhibited convulsions induced by the gamma-aminobutyric acid type A (GABAa) receptor antagonist, pentylenetetrazole (PTZ), in a dose dependent manner. The extracts also exhibited low toxicity against brine shrimps giving LC(50) values between 45.4 and 95.4 microg/ml. These results provide evidence for the potential of D. fischeri extracts to treat absence seizures, especially given their seemingly innocuous nature.

Entities:  

Keywords:  Anticonvulsant activity; Brine shrimp toxicity; Diospyros fischeri; Pentylenetetrazole

Year:  2006        PMID： 20162096      PMCID： PMC2816445     

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  7 in total

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Authors:  Mainen J Moshi; Godeliver A B Kagashe; Zakaria H Mbwambo
Journal:  J Ethnopharmacol       Date:  2005-01-01       Impact factor: 4.360

2.  Some pharmacological properties of extracts of Terminalia sericea roots.

Authors:  M J Moshi; Z H Mbwambo
Journal:  J Ethnopharmacol       Date:  2004-12-15       Impact factor: 4.360

3.  Brine shrimp: a convenient general bioassay for active plant constituents.

Authors:  B N Meyer; N R Ferrigni; J E Putnam; L B Jacobsen; D E Nichols; J L McLaughlin
Journal:  Planta Med       Date:  1982-05       Impact factor: 3.352

4.  Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.

Authors:  R Q Huang; C L Bell-Horner; M I Dibas; D F Covey; J A Drewe; G H Dillon
Journal:  J Pharmacol Exp Ther       Date:  2001-09       Impact factor: 4.030

5.  Prognosis of epilepsy in a rural African community: a 30-year follow-up of 164 patients in an outpatient clinic in rural Tanzania.

Authors:  L Jilek-Aall; H T Rwiza
Journal:  Epilepsia       Date:  1992 Jul-Aug       Impact factor: 5.864

6.  Knowledge, attitude and practice (KAP) towards epilepsy in secondary school students in Tanzania.

Authors:  W B Matuja; H T Rwiza
Journal:  Cent Afr J Med       Date:  1994-01

7.  Prevalence and incidence of epilepsy in Ulanga, a rural Tanzanian district: a community-based study.

Authors:  H T Rwiza; G P Kilonzo; J Haule; W B Matuja; I Mteza; P Mbena; P M Kilima; G Mwaluko; R Mwang'ombola; F Mwaijande
Journal:  Epilepsia       Date:  1992 Nov-Dec       Impact factor: 5.864
  7 in total

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