Literature DB >> 20162054

In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice.

Charles Mutai1, Geoffrey Rukunga, Constatinos Vagias, Vassilios Roussis.   

Abstract

The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.

Entities:  

Keywords:  Acacia mellifera; Antimalarial activity; lupane triterpenes; mice

Year:  2007        PMID： 20162054      PMCID： PMC2816603     

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  17 in total

Review 1.  Drug resistance in malaria parasites of animals and man.

Authors:  W Peters
Journal:  Adv Parasitol       Date:  1998       Impact factor: 3.870

2.  Traditional healers in Tanzania: the treatment of malaria with plant remedies.

Authors:  M C Gessler; D E Msuya; M H Nkunya; L B Mwasumbi; A Schär; M Heinrich; M Tanner
Journal:  J Ethnopharmacol       Date:  1995-11-03       Impact factor: 4.360

Review 3.  Antimalarial agents: mechanism of chloroquine resistance.

Authors:  D J Krogstad; P H Schlesinger; B L Herwaldt
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

Review 4.  Antimalarial drug resistance: an increasing problem.

Authors:  W Peters
Journal:  Br Med Bull       Date:  1982-05       Impact factor: 4.291

Review 5.  Artemisinin: an endoperoxidic antimalarial from Artemisia annua L.

Authors:  H Ziffer; R J Highet; D L Klayman
Journal:  Fortschr Chem Org Naturst       Date:  1997

6.  In vitro and in vivo evaluation of betulinic acid as an antimalarial.

Authors:  J C Steele; D C Warhurst; G C Kirby; M S Simmonds
Journal:  Phytother Res       Date:  1999-03       Impact factor: 5.878

7.  Quaternary alkaloids of tinospora species.

Authors:  N G Bisset; J Nwaiwu
Journal:  Planta Med       Date:  1983-08       Impact factor: 3.352

8.  Antiplasmodial triterpene from Vernonia brasiliana.

Authors:  T M Alves; T J Nagem; L H de Carvalho; A U Krettli; C L Zani
Journal:  Planta Med       Date:  1997-12       Impact factor: 3.352

9.  Cytotoxic lupane-type triterpenoids from Acacia mellifera.

Authors:  Charles Mutai; Dennis Abatis; Constantinos Vagias; Dimitri Moreau; Christos Roussakis; Vassilios Roussis
Journal:  Phytochemistry       Date:  2004-04       Impact factor: 4.072

Review 10.  Drug resistance in malaria: a review of the west African situation.

Authors:  K O Adubofour
Journal:  J Natl Med Assoc       Date:  1992-12       Impact factor: 1.798
View more
  2 in total

1.  In vivo anti-malarial activity and toxicity studies of triterpenic esters isolated form Keetia leucantha and crude extracts.

Authors:  Claire Beaufay; Marie-France Hérent; Joëlle Quetin-Leclercq; Joanne Bero
Journal:  Malar J       Date:  2017-10-10       Impact factor: 2.979

2.  Hepatoprotective and antiviral efficacy of Acacia mellifera leaves fractions against hepatitis B virus.

Authors:  Ahmed H Arbab; Mohammad K Parvez; Mohammed S Al-Dosari; Adnan J Al-Rehaily; Mohammed Al-Sohaibani; Elwaleed E Zaroug; Mansour S AlSaid; Syed Rafatullah
Journal:  Biomed Res Int       Date:  2015-04-09       Impact factor: 3.411
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.