Literature DB >> 20161635

First Multi-gram Preparation SCP-123, A Novel Water Soluble Analgesic.

Lei Miao1, Liang Xu, Kenneth W Narducy, Mark L Trudell.   

Abstract

A short multi-gram process for the preparation of the analgesic compound SCP-123 (4) and its n class="Chemical">sodium salt has been developed.

Entities:  

Year:  2009        PMID： 20161635      PMCID： PMC2814521          DOI： 10.1021/op900113b

Source DB:  PubMed          Journal:  Org Process Res Dev        ISSN： 1083-6160            Impact factor:   3.317


  8 in total

1.  Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain.

Authors:  Jian-Guo Cui; Xiong Zhang; Yu-Hai Zhao; Chu Chen; Nicolas Bazan
Journal:  Biochem Biophys Res Commun       Date:  2006-09-22       Impact factor: 3.575

Review 2.  The complex interaction between ethanol and acetaminophen.

Authors:  J T Slattery; S D Nelson; K E Thummel
Journal:  Clin Pharmacol Ther       Date:  1996-09       Impact factor: 6.875

Review 3.  Nonnarcotic analgesics: prevalence and estimated economic impact of toxicities.

Authors:  M D McGoldrick; G R Bailie
Journal:  Ann Pharmacother       Date:  1997-02       Impact factor: 3.154

4.  Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs.

Authors:  Anthony L Vaccarino; Dennis Paul; Pranab K Mukherjee; Elena B Rodríguez de Turco; Victor L Marcheselli; Liang Xu; Mark L Trudell; J M Minguez; M P Matía; Carlos Sunkel; Julio Alvarez-Builla; Nicolas G Bazan
Journal:  Bioorg Med Chem       Date:  2006-08-21       Impact factor: 3.641

Review 5.  Paracetamol: past, present, and future.

Authors:  L F Prescott
Journal:  Am J Ther       Date:  2000-03       Impact factor: 2.688

6.  Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial.

Authors:  Paul B Watkins; Neil Kaplowitz; John T Slattery; Connie R Colonese; Salvatore V Colucci; Paul W Stewart; Stephen C Harris
Journal:  JAMA       Date:  2006-07-05       Impact factor: 56.272

7.  Influence of medium and temperature on the hydrolysis kinetics of propacetamol hydrochloride: determination using derivative spectrophotometry.

Authors:  Emilia Barcia; Alicia Martin; Ma Luz Azuara; Sofia Negro
Journal:  Chem Pharm Bull (Tokyo)       Date:  2005-03       Impact factor: 1.645

8.  Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use.

Authors:  M Depré; A van Hecken; R Verbesselt; T B Tjandra-Maga; M Gerin; P J de Schepper
Journal:  Fundam Clin Pharmacol       Date:  1992       Impact factor: 2.748
  8 in total
  2 in total

1.  Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1.

Authors:  Nieves Fresno; Ruth Pérez-Fernández; Carlos Goicoechea; Ibon Alkorta; Asia Fernández-Carvajal; Roberto de la Torre-Martínez; Susana Quirce; Antonio Ferrer-Montiel; M Isabel Martín; Pilar Goya; José Elguero
Journal:  PLoS One       Date:  2014-12-01       Impact factor: 3.240

2.  A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis.

Authors:  Hernan A Bazan; Surjyadipta Bhattacharjee; Carolina Burgos; Javier Recio; Valentina Abet; Amanda R Pahng; Bokkyoo Jun; Jessica Heap; Alexander J Ledet; William C Gordon; Scott Edwards; Dennis Paul; Julio Alvarez-Builla; Nicolas G Bazan
Journal:  Eur J Med Chem       Date:  2020-06-30       Impact factor: 6.514
  2 in total

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