| Literature DB >> 20161301 |
Baoshun Ma1, Vincent Ruwet, Patricia Corieri, Raf Theunissen, Michel Riethmuller, Chantal Darquenne.
Abstract
Accurate modeling of air flow and aerosol transport in the alveolated airways is essential for quantitative predictions of pulmonary aerosol deposition. However, experimental validation of such modeling studies has been scarce. The objective of this study is to validate CFD predictions of flow field and particle trajectory with experiments within a scaled-up model of alveolated airways. Steady flow (Re = 0.13) of silicone oil was captured by particle image velocimetry (PIV), and the trajectories of 0.5 mm and 1.2 mm spherical iron beads (representing 0.7 to 14.6 mum aerosol in vivo) were obtained by particle tracking velocimetry (PTV). At twelve selected cross sections, the velocity profiles obtained by CFD matched well with those by PIV (within 1.7% on average). The CFD predicted trajectories also matched well with PTV experiments. These results showed that air flow and aerosol transport in models of human alveolated airways can be simulated by CFD techniques with reasonable accuracy.Entities:
Year: 2009 PMID： 20161301 PMCID： PMC2699293 DOI： 10.1016/j.jaerosci.2009.01.002
Source DB: PubMed Journal: J Aerosol Sci ISSN： 0021-8502 Impact factor: 3.433