| Literature DB >> 20160953 |
H T Banks1, Kathleen Holm, Nathan C Wanner, Ariel Cintrón-Arias, Grace M Kepler, Jeffrey D Wetherington.
Abstract
We present a preliminary first-pass dynamic model for delivery of drug compounds to the lungs and heart. We use a compartmental mass balance approach to develop a system of nonlinear differential equations for mass accumulated in the heart as a result of intravenous injection. We discuss sensitivity analysis as well as methodology for minimizing mass in the heart while maximizing mass delivered to the lungs on a first circulatory pass.Entities:
Year: 2009 PMID： 20160953 PMCID： PMC2768143 DOI： 10.1016/j.mcm.2009.02.007
Source DB: PubMed Journal: Math Comput Model ISSN： 0895-7177