Literature DB >> 2016074

Oxygen free radicals and Parkinson's disease.

J D Adams1, I N Odunze.   

Abstract

The involvement of oxygen radicals in the pathogenesis of Parkinson's disease has been suggested for some time. This article reviews the evidence supporting the involvement of oxygen radicals in the disease process in the brain. This includes a discussion of iron, lipid peroxidation, peroxidase, catalase, superoxide dismutase, and glutathione levels in the brain. In addition, various theories of induction of Parkinson's disease are discussed in relation to the possible involvement of oxygen radicals. These theories include the environmental toxin theory, the dopamine turnover theory, and the cerebral blood flow theory.

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Year:  1991        PMID： 2016074     DOI： 10.1016/0891-5849(91)90009-r

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  37 in total

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4.  Role of oxidative stress in the antitumoral action of a new vanadyl(IV) complex with the flavonoid chrysin in two osteoblast cell lines: relationship with the radical scavenger activity.

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7.  Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole.

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Journal:  Neurotox Res       Date:  2009-02-10       Impact factor: 3.911

9.  Dopaminergic system activity and cellular defense mechanisms in the striatum and striatal synaptosomes of the rat subchronically exposed to manganese.

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10.  Pharmacokinetics, tissue distribution and excretion of manganese (III) meso-tetra [3-(2-(2-methoxy)-ethoxy) ethoxy] phenyl porphyrin chloride, a novel superoxide dismutase mimic, in Wistar rats.

Authors:  Bao-Qiu Li; Shi-Hong Fang; Xin Dong; Na Li; Ji-You Gao; Gui-Qin Yang; Xian-Chang Gong; Shu-Juan Wang; Feng-Shan Wang
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2013-01-26       Impact factor: 2.441
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