BACKGROUND: Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. OBJECTIVES: To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. METHODS: The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. RESULTS: Of the 3 polymorphisms studied, only the distribution of the MMP-9 -1562C-->T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45-0.98; p = 0.04). CONCLUSIONS: These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population. Copyright 2010 S. Karger AG, Basel.
BACKGROUND: Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. OBJECTIVES: To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. METHODS: The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. RESULTS: Of the 3 polymorphisms studied, only the distribution of the MMP-9 -1562C-->T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45-0.98; p = 0.04). CONCLUSIONS: These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population. Copyright 2010 S. Karger AG, Basel.
Authors: Jeanine M D'Armiento; Monica P Goldklang; Andrew A Hardigan; Patrick Geraghty; Michael D Roth; John E Connett; Robert A Wise; Frank C Sciurba; Steven M Scharf; Jincy Thankachen; Monirul Islam; Andrew J Ghio; Robert F Foronjy Journal: PLoS One Date: 2013-02-18 Impact factor: 3.240