Time course changes in glycogen accretion, 6-phosphogluconate, fructose-2,6-bisphosphate, and lipogenesis upon refeeding a high sucrose diet to starved rats.

1. Starved rats refed 60% sucrose diets were used to determine in vivo lipogenesis and levels of hepatic metabolites. 2. Fatty acid synthesis increased 11-fold 4 hr after refeeding. 3. Glycogen rose from 3 to 100 mg/g liver after 8 hr. 4. Fructose-2,6-bisphosphate rose to 6 nmol/g at 1 hr and remained constant. 5. 6-Phosphogluconate increased from 10 to 45 nmol/g liver after 2 hr and remained constant.