Literature DB >> 20159179

A randomized prospective trial comparing the levonorgestrel-releasing intrauterine system with thermal balloon ablation for the treatment of heavy menstrual bleeding.

Sérgio S de Souza1, Aroldo F Camargos, Carolina P de Rezende, Francisco A N Pereira, Cícero A A Araújo, Agnaldo L Silva Filho.   

Abstract

BACKGROUND: Use of the levonorgestrel-releasing intrauterine system (LNG-IUS) was compared with thermal balloon ablation (TBA) for the treatment of heavy menstrual bleeding (HMB). STUDY
DESIGN: A prospective randomized trial comparing the LNG-IUS (n=30 women) and TBA (n=28 women).
RESULTS: Hemoglobin levels increased (p<.001) and blood loss was reduced (p<.001) in both groups after 1 year of treatment. Menstrual bleeding was less in the LNG-IUS group compared to the TBA group at 6 and 12 months of treatment (p=.035 and p=.048, respectively). Intermenstrual bleeding was significantly less in the TBA group at 6 months compared to the LNG-IUS group (p=.044); however, there was no significant difference at 12 months (p=.129). No difference was found in psychological aspects between pre- and posttreatment variables in either of the groups (p=.537).
CONCLUSIONS: Both the LNG-IUS and TBA appear to be effective in controlling HMB; however, posttreatment uterine bleeding patterns are different. Copyright (c) 2010 Elsevier Inc. All rights reserved.

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Year:  2009        PMID: 20159179     DOI: 10.1016/j.contraception.2009.09.012

Source DB:  PubMed          Journal:  Contraception        ISSN: 0010-7824            Impact factor:   3.375


  10 in total

Review 1.  The levonorgestrel-releasing intrauterine system in heavy menstrual bleeding: a benefit-risk review.

Authors:  Andrew M Kaunitz; Pirjo Inki
Journal:  Drugs       Date:  2012-01-22       Impact factor: 9.546

Review 2.  Levonorgestrel-Releasing Intrauterine System (52 mg) for Idiopathic Heavy Menstrual Bleeding: A Health Technology Assessment.

Authors: 
Journal:  Ont Health Technol Assess Ser       Date:  2016-11-01

Review 3.  Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta-analysis.

Authors:  Magdalena Bofill Rodriguez; Sofia Dias; Vanessa Jordan; Anne Lethaby; Sarah F Lensen; Michelle R Wise; Jack Wilkinson; Julie Brown; Cindy Farquhar
Journal:  Cochrane Database Syst Rev       Date:  2022-05-31

4.  Endometrial cancer after endometrial ablation vs medical management of abnormal uterine bleeding.

Authors:  Robert L Dood; Clarisa R Gracia; Mary D Sammel; Kevin Haynes; Suneeta Senapati; Brian L Strom
Journal:  J Minim Invasive Gynecol       Date:  2014-02-28       Impact factor: 4.137

Review 5.  Surgery versus medical therapy for heavy menstrual bleeding.

Authors:  Jane Marjoribanks; Anne Lethaby; Cindy Farquhar
Journal:  Cochrane Database Syst Rev       Date:  2016-01-29

6.  A randomized clinical trial to compare levonorgestrel-releasing intrauterine system (Mirena) vs trans-cervical endometrial resection for treatment of menorrhagia.

Authors:  Shirin Ghazizadeh; Fatemeh Bakhtiari; Haleh Rahmanpour; Fatemeh Davari-Tanha; Fatemeh Ramezanzadeh
Journal:  Int J Womens Health       Date:  2011-07-20

7.  Endometrial resection and ablation techniques for heavy menstrual bleeding.

Authors:  Magdalena Bofill Rodriguez; Anne Lethaby; Mihaela Grigore; Julie Brown; Martha Hickey; Cindy Farquhar
Journal:  Cochrane Database Syst Rev       Date:  2019-01-22

8.  Progestogen-releasing intrauterine systems for heavy menstrual bleeding.

Authors:  Magdalena Bofill Rodriguez; Anne Lethaby; Vanessa Jordan
Journal:  Cochrane Database Syst Rev       Date:  2020-06-12

9.  Levonorgestrel intrauterine system versus thermal balloon ablation for the treatment of heavy menstrual bleeding: A meta-analysis of randomized controlled trials.

Authors:  Bing-Qing Yang; Jie-Han Xu; Yin-Cheng Teng
Journal:  Exp Ther Med       Date:  2015-09-07       Impact factor: 2.447

Review 10.  Femilis(®) 60 Levonorgestrel-Releasing Intrauterine System-A Review of 10 Years of Clinical Experience.

Authors:  Dirk Wildemeersch; Amaury Andrade; Norman Goldstuck
Journal:  Clin Med Insights Reprod Health       Date:  2016-08-09
  10 in total

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