Literature DB >> 20159146

Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.

Liang Qiao1, Hannah Phipps-Yonas, Boris Hartmann, Thomas M Moran, Stuart C Sealfon, Fernand Hayot.   

Abstract

The pretreatment of human dendritic cells with interferon-beta enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20159146      PMCID： PMC2820658          DOI： 10.1016/j.bpj.2009.10.049

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


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