| Literature DB >> 20159052 |
Yiting Tang1, Bingxin Li, Nasui Wang, Yanyun Xie, Linghao Wang, Qiongjing Yuan, Fangfang Zhang, Jiao Qin, Zhangzhe Peng, Wangbin Ning, Ling Wang, Gaoyun Hu, Jing Li, Lijian Tao.
Abstract
The pathogenesis of sepsis is mediated in part by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release proinflammatory factors like TNF-alpha and IL-1beta. Fluorofenidone (AKF-PD) is a novel pyridone agent, which exerts a strong antifibrotic effect. In this work, we showed that AKF-PD also exert an inhibitory effect on acute systemic inflammatory response. AKF-PD treatment significantly increased survival in animals with established endotoxemia. In addition, AKF-PD treatment significantly reduced circulating levels of TNF-alpha and IL-1beta during endotoxemia. In macrophage cultures, AKF-PD inhibited the release of TNF-alpha and IL-1beta in a dose-dependent manner. In conclusion, these results indicate that AKF-PD inhibits the release of the proinflammatory cytokines (TNF-a and IL-1beta) and improves survival during lethal endotoxemia, which suggest this new pyridone agent can be a novel candidate for therapy of septic shock. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20159052 DOI： 10.1016/j.intimp.2010.02.005
Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932