Literature DB >> 20158937

Metabolomic systems biology of trypanosomes.

Michael P Barrett1, Barbara M Bakker, Rainer Breitling.   

Abstract

Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental perturbation, and to identify the targets of drugs. Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research.

Mesh：

Year:  2010        PMID： 20158937     DOI： 10.1017/S003118201000017X

Source DB:  PubMed          Journal:  Parasitology        ISSN： 0031-1820            Impact factor:   3.234


  8 in total

Review 1.  Systems biology from micro-organisms to human metabolic diseases: the role of detailed kinetic models.

Authors:  Barbara M Bakker; Karen van Eunen; Jeroen A L Jeneson; Natal A W van Riel; Frank J Bruggeman; Bas Teusink
Journal:  Biochem Soc Trans       Date:  2010-10       Impact factor: 5.407

Review 2.  Trypanosoma brucei: Metabolomics for analysis of cellular metabolism and drug discovery.

Authors:  Fanta Fall; Lucia Mamede; Laura Schioppa; Allison Ledoux; Pascal De Tullio; Paul Michels; Michel Frédérich; Joëlle Quetin-Leclercq
Journal:  Metabolomics       Date:  2022-03-19       Impact factor: 4.290

Review 3.  The silicon trypanosome: a test case of iterative model extension in systems biology.

Authors:  Fiona Achcar; Abeer Fadda; Jurgen R Haanstra; Eduard J Kerkhoven; Dong-Hyun Kim; Alejandro E Leroux; Theodore Papamarkou; Federico Rojas; Barbara M Bakker; Michael P Barrett; Christine Clayton; Mark Girolami; R Luise Krauth-Siegel; Keith R Matthews; Rainer Breitling
Journal:  Adv Microb Physiol       Date:  2014       Impact factor: 3.517

Review 4.  25 years of African trypanosome research: From description to molecular dissection and new drug discovery.

Authors:  Keith R Matthews
Journal:  Mol Biochem Parasitol       Date:  2015-02-28       Impact factor: 1.759

5.  Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

Authors:  Andrea Trochine; Darren J Creek; Paula Faral-Tello; Michael P Barrett; Carlos Robello
Journal:  PLoS Negl Trop Dis       Date:  2014-05-22

6.  Multi Platforms Strategies and Metabolomics Approaches for the Investigation of Comprehensive Metabolite Profile in Dogs with Babesia canis Infection.

Authors:  Ivana Rubić; Richard Burchmore; Stefan Weidt; Clement Regnault; Josipa Kuleš; Renata Barić Rafaj; Tomislav Mašek; Anita Horvatić; Martina Crnogaj; Peter David Eckersall; Predrag Novak; Vladimir Mrljak
Journal:  Int J Mol Sci       Date:  2022-01-29       Impact factor: 5.923

Review 7.  Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics.

Authors:  Ritika Kabra; Nutan Chauhan; Anurag Kumar; Prajakta Ingale; Shailza Singh
Journal:  Prog Biophys Mol Biol       Date:  2018-07-18       Impact factor: 3.667

8.  Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

Authors:  Isabel M Vincent; Darren J Creek; Karl Burgess; Debra J Woods; Richard J S Burchmore; Michael P Barrett
Journal:  PLoS Negl Trop Dis       Date:  2012-05-01
  8 in total

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