PURPOSE: To determine the Galectin-1 protein expression in oral squamous cell carcinoma (OSCC). METHODS: Comparative proteomic analysis of an in vitro cellular carcinogenesis model of OSCC we previously established was performed to identify differentially expressed proteins. Galectin-1 was further validated in vitro (human immortalized oral epithelia cell line and OSCC lines) and in vivo (tissue samples from OSCC patients) by Western blotting and immunohistochemistry, respectively. RESULTS: Increased Galectin-1 protein expression was identified in the cancerous cell line compared with the immortalized oral epithelial cell line in the in vitro cellular carcinogenesis model, and then validated in the OSCC lines and cancerous tissues. Galectin-1 protein expression was negatively correlated with the tumor pathologic differentiation grades, a higher Galectin-1 protein expression indicating a poorer pathologic differentiation grade. CONCLUSIONS: Galectin-1 protein expression level increases in OSCC, it may serve as a candidate marker for pathologic differentiation grade of OSCC.
PURPOSE: To determine the Galectin-1 protein expression in oral squamous cell carcinoma (OSCC). METHODS: Comparative proteomic analysis of an in vitro cellular carcinogenesis model of OSCC we previously established was performed to identify differentially expressed proteins. Galectin-1 was further validated in vitro (human immortalized oral epithelia cell line and OSCC lines) and in vivo (tissue samples from OSCC patients) by Western blotting and immunohistochemistry, respectively. RESULTS: Increased Galectin-1 protein expression was identified in the cancerous cell line compared with the immortalized oral epithelial cell line in the in vitro cellular carcinogenesis model, and then validated in the OSCC lines and cancerous tissues. Galectin-1 protein expression was negatively correlated with the tumor pathologic differentiation grades, a higher Galectin-1 protein expression indicating a poorer pathologic differentiation grade. CONCLUSIONS:Galectin-1 protein expression level increases in OSCC, it may serve as a candidate marker for pathologic differentiation grade of OSCC.
Authors: G Choufani; N Nagy; S Saussez; H Marchant; P Bisschop; M Burchert; A Danguy; S Louryan; I Salmon; H J Gabius; R Kiss; S Hassid Journal: Cancer Date: 1999-12-01 Impact factor: 6.860
Authors: Quynh-Thu Le; Christina Kong; Phillip W Lavori; Ken O'byrne; Janine T Erler; Xin Huang; Yijun Chen; Hongbin Cao; Robert Tibshirani; Nic Denko; Amato J Giaccia; Albert C Koong Journal: Int J Radiat Oncol Biol Phys Date: 2007-09-01 Impact factor: 7.038
Authors: Ru Chen; Sheng Pan; Niki A Ottenhof; Roeland F de Wilde; Christopher L Wolfgang; Zhaoli Lane; Jane Post; Mary P Bronner; Jürgen K Willmann; Anirban Maitra; Teresa A Brentnall Journal: Cancer Biol Ther Date: 2012-08-01 Impact factor: 4.742