BACKGROUND: A variety of catheter-based energy modalities are used for cardiac ablation to treat arrhythmias. Robotic radiosurgery is increasingly being utilized to successfully accomplish precise tissue ablation in anatomically remote areas. OBJECTIVE: The purpose of this study was to examine the experimental feasibility of a noninvasive method using stereotactic robotic radiosurgery (SRS) to create cardiac lesions. METHODS: Sixteen (16) Hanford-Sinclair mini swine (weight 40-70 kg) under general anesthesia were studied. Baseline computed tomographic scans were performed, followed by electroanatomic mapping using the CARTO system. Stereotactic robotic radiosurgery was performed using the CyberHeart system, with predetermined targets at the cavotricuspid isthmus, AV node, pulmonary vein-left atrial junction, or left atrial appendage. From 25 to 196 days after treatment, the animals were investigated with repeat electroanatomic voltage mapping and transesophageal echocardiography, when possible. The animals then were sacrificed and pathology specimens taken. RESULTS: Dose ranging suggested that 25 Gy was needed to produce an electrophysiologic effect. The time course showed an electrophysiologic effect consistently by 90 days. The method was feasible for producing bidirectional cavotricuspid isthmus block and AV nodal conduction block. The pulmonary vein-left atrial junction and left atrial appendage showed marked voltage reduction to less than 0.05 mV. No spontaneous arrhythmias were observed. Pathology specimens showed no evidence of radiation damage outside the target. Histology samples from target sites showed effects consistent with X-beam radiation. CONCLUSION: Stereotactic robotic radiosurgery can produce cavotricuspid isthmus block, AV nodal block, and significant decreased voltage at the pulmonary vein-left atrial junction. No other organ damage was seen. The study findings demonstrate the feasibility of this noninvasive treatment method for creating cardiac lesions. This approach merits further investigation in the treatment of arrhythmias. Copyright (c) 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
BACKGROUND: A variety of catheter-based energy modalities are used for cardiac ablation to treat arrhythmias. Robotic radiosurgery is increasingly being utilized to successfully accomplish precise tissue ablation in anatomically remote areas. OBJECTIVE: The purpose of this study was to examine the experimental feasibility of a noninvasive method using stereotactic robotic radiosurgery (SRS) to create cardiac lesions. METHODS: Sixteen (16) Hanford-Sinclair mini swine (weight 40-70 kg) under general anesthesia were studied. Baseline computed tomographic scans were performed, followed by electroanatomic mapping using the CARTO system. Stereotactic robotic radiosurgery was performed using the CyberHeart system, with predetermined targets at the cavotricuspid isthmus, AV node, pulmonary vein-left atrial junction, or left atrial appendage. From 25 to 196 days after treatment, the animals were investigated with repeat electroanatomic voltage mapping and transesophageal echocardiography, when possible. The animals then were sacrificed and pathology specimens taken. RESULTS: Dose ranging suggested that 25 Gy was needed to produce an electrophysiologic effect. The time course showed an electrophysiologic effect consistently by 90 days. The method was feasible for producing bidirectional cavotricuspid isthmus block and AV nodal conduction block. The pulmonary vein-left atrial junction and left atrial appendage showed marked voltage reduction to less than 0.05 mV. No spontaneous arrhythmias were observed. Pathology specimens showed no evidence of radiation damage outside the target. Histology samples from target sites showed effects consistent with X-beam radiation. CONCLUSION: Stereotactic robotic radiosurgery can produce cavotricuspid isthmus block, AV nodal block, and significant decreased voltage at the pulmonary vein-left atrial junction. No other organ damage was seen. The study findings demonstrate the feasibility of this noninvasive treatment method for creating cardiac lesions. This approach merits further investigation in the treatment of arrhythmias. Copyright (c) 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
Authors: Edmond M Cronin; Frank M Bogun; Philippe Maury; Petr Peichl; Minglong Chen; Narayanan Namboodiri; Luis Aguinaga; Luiz Roberto Leite; Sana M Al-Khatib; Elad Anter; Antonio Berruezo; David J Callans; Mina K Chung; Phillip Cuculich; Andre d'Avila; Barbara J Deal; Paolo Della Bella; Thomas Deneke; Timm-Michael Dickfeld; Claudio Hadid; Haris M Haqqani; G Neal Kay; Rakesh Latchamsetty; Francis Marchlinski; John M Miller; Akihiko Nogami; Akash R Patel; Rajeev Kumar Pathak; Luis C Saenz Morales; Pasquale Santangeli; John L Sapp; Andrea Sarkozy; Kyoko Soejima; William G Stevenson; Usha B Tedrow; Wendy S Tzou; Niraj Varma; Katja Zeppenfeld Journal: J Interv Card Electrophysiol Date: 2020-10 Impact factor: 1.900
Authors: Yong Wang; Phillip S Cuculich; Junjie Zhang; Kavit A Desouza; Ramya Vijayakumar; Jane Chen; Mitchell N Faddis; Bruce D Lindsay; Timothy W Smith; Yoram Rudy Journal: Sci Transl Med Date: 2011-08-31 Impact factor: 17.956
Authors: Clifford G Robinson; Pamela P Samson; Kaitlin M S Moore; Geoffrey D Hugo; Nels Knutson; Sasa Mutic; S Murty Goddu; Adam Lang; Daniel H Cooper; Mitchell Faddis; Amit Noheria; Timothy W Smith; Pamela K Woodard; Robert J Gropler; Dennis E Hallahan; Yoram Rudy; Phillip S Cuculich Journal: Circulation Date: 2019-01-15 Impact factor: 29.690
Authors: Daniel Buergy; Boris Rudic; Erol Tueluemen; Benjamin Gauter-Fleckenstein; Martin Borggrefe; Frederik Wenz Journal: Strahlenther Onkol Date: 2018-05 Impact factor: 3.621
Authors: Phillip S Cuculich; Matthew R Schill; Rojano Kashani; Sasa Mutic; Adam Lang; Daniel Cooper; Mitchell Faddis; Marye Gleva; Amit Noheria; Timothy W Smith; Dennis Hallahan; Yoram Rudy; Clifford G Robinson Journal: N Engl J Med Date: 2017-12-14 Impact factor: 91.245
Authors: Edmond M Cronin; Frank M Bogun; Philippe Maury; Petr Peichl; Minglong Chen; Narayanan Namboodiri; Luis Aguinaga; Luiz Roberto Leite; Sana M Al-Khatib; Elad Anter; Antonio Berruezo; David J Callans; Mina K Chung; Phillip Cuculich; Andre d'Avila; Barbara J Deal; Paolo Della Bella; Thomas Deneke; Timm-Michael Dickfeld; Claudio Hadid; Haris M Haqqani; G Neal Kay; Rakesh Latchamsetty; Francis Marchlinski; John M Miller; Akihiko Nogami; Akash R Patel; Rajeev Kumar Pathak; Luis C Sáenz Morales; Pasquale Santangeli; John L Sapp; Andrea Sarkozy; Kyoko Soejima; William G Stevenson; Usha B Tedrow; Wendy S Tzou; Niraj Varma; Katja Zeppenfeld Journal: Europace Date: 2019-08-01 Impact factor: 5.214
Authors: Ping Xia; Rupesh Kotecha; Naveen Sharma; Martin Andrews; Kevin L Stephans; Carlos Oberti; Sara Lin; Oussama Wazni; Patrick Tchou; Walid I Saliba; John Suh Journal: Cureus Date: 2016-07-11
Authors: David Krug; Oliver Blanck; Thomas Demming; Matthias Dottermusch; Karoline Koch; Markus Hirt; Laura Kotzott; Adrian Zaman; Lina Eidinger; Frank-Andre Siebert; Jürgen Dunst; Hendrik Bonnemeier Journal: Strahlenther Onkol Date: 2019-10-31 Impact factor: 3.621