BACKGROUND: Epicardial adipose tissue has shown to be related to cardiovascular risk. The aim of this study is to investigate the relationship between epicardial adiposity and endothelial function in metabolic syndrome. METHODS: Fifty patients with metabolic syndrome were recruited. Anthropometric measurements, fasting blood glucose, insulin, lipid profile, high-sensitivity C-reactive protein (hsCRP), fibrinogen, apolipoprotein A (Apo A), Apo B1, and lipoprotein (a) [Lp(a)] were determined. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Epicardial fat thickness was measured via two-dimensional M-mode echocardiography. Endothelial function was assessed as flow-mediated dilatation at the brachial artery. RESULTS: Epicardial fat tissue thickness was shown to be correlated negatively with FMD and positively with age, diastolic blood pressure, hsCRP, fibrinogen, HOMA-IR, and lipid parameters. Multiple regression analysis showed epicardial fat tissue thickness to be an independent factor influencing the endothelial function. CONCLUSIONS: Epicardial fat tissue may be a useful parameter in the assessment of patients with metabolic syndrome.
BACKGROUND: Epicardial adipose tissue has shown to be related to cardiovascular risk. The aim of this study is to investigate the relationship between epicardial adiposity and endothelial function in metabolic syndrome. METHODS: Fifty patients with metabolic syndrome were recruited. Anthropometric measurements, fasting blood glucose, insulin, lipid profile, high-sensitivity C-reactive protein (hsCRP), fibrinogen, apolipoprotein A (Apo A), Apo B1, and lipoprotein (a) [Lp(a)] were determined. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Epicardial fat thickness was measured via two-dimensional M-mode echocardiography. Endothelial function was assessed as flow-mediated dilatation at the brachial artery. RESULTS: Epicardial fat tissue thickness was shown to be correlated negatively with FMD and positively with age, diastolic blood pressure, hsCRP, fibrinogen, HOMA-IR, and lipid parameters. Multiple regression analysis showed epicardial fat tissue thickness to be an independent factor influencing the endothelial function. CONCLUSIONS: Epicardial fat tissue may be a useful parameter in the assessment of patients with metabolic syndrome.
Authors: Haim Shmilovich; Damini Dey; Victor Y Cheng; Ronak Rajani; Ryo Nakazato; Yuka Otaki; Rine Nakanishi; Piotr J Slomka; Louise E J Thomson; Sean W Hayes; John D Friedman; Heidi Gransar; Nathan D Wong; Leslee J Shaw; Matthew Budoff; Alan Rozanski; Daniel S Berman Journal: Am J Cardiol Date: 2011-08-30 Impact factor: 2.778
Authors: Vincent Dunet; François Feihl; Amin Dabiri; Gilles Allenbach; Bernard Waeber; Raphaël Heinzer; John O Prior Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-19 Impact factor: 9.236