| Literature DB >> 20156061 |
Jamie P Nourse1, Kimberley Jones, Ujjwal Dua, Naomi Runnegar, David Looke, Chris Schmidt, Siok-Keen Tey, Glen Kennedy, Maher K Gandhi.
Abstract
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20156061 DOI： 10.1086/650007
Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079