Literature DB >> 2015500

Effect of acidosis on lipid peroxidation in brain slices.

J Bralet1, C Bouvier, L Schreiber, M Boquillon.   

Abstract

Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes. These results support the hypothesis that free radical mechanisms may be involved in the cytotoxicity of acidosis.

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Year:  1991        PMID： 2015500     DOI： 10.1016/0006-8993(91)90703-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Crossover effects of acidosis on the recovery of neuronal function following glucose-oxygen deprivation in rat hippocampal slices.

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2.  An in vivo ESR spin-trapping study: free radical generation in rats from formate intoxication--role of the Fenton reaction.

Authors:  A E Dikalova; M B Kadiiska; R P Mason
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3.  Effect of low pH on glutamate uptake and release in isolated presynaptic endings from rat brain.

Authors:  Sergei V Fedorovich; Gregory V Kaler; Sergei V Konev
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4.  Acidosis-induced modifications of high-affinity choline uptake by synaptosomes: effects of pH readjustment.

Authors:  J M Cancela; A Beley
Journal:  Neurochem Res       Date:  1995-07       Impact factor: 3.996

5.  Effects of iron-induced lipid peroxidation and of acidosis on choline uptake by synaptosomes.

Authors:  J M Cancela; J Bralet; A Beley
Journal:  Neurochem Res       Date:  1994-07       Impact factor: 3.996

6.  Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia.

Authors:  R V Dimlich; P J Marangos
Journal:  J Mol Neurosci       Date:  1994       Impact factor: 3.444

7.  Influence of intra- and extracellular acidification on free radical formation and mitochondria membrane potential in rat brain synaptosomes.

Authors:  Tatyana G Pekun; Valeriya V Lemeshchenko; Tamara I Lyskova; Tatyana V Waseem; Sergei V Fedorovich
Journal:  J Mol Neurosci       Date:  2012-11-06       Impact factor: 3.444

8.  Hypoxia-induced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine.

Authors:  Hana Rauchová; Jitka Koudelová; Zdenĕk Drahota; Jindrich Mourek
Journal:  Neurochem Res       Date:  2002-09       Impact factor: 3.996

9.  Citicoline protects brain against closed head injury in rats through suppressing oxidative stress and calpain over-activation.

Authors:  Ke Qian; Yi Gu; Yumei Zhao; Zhenzong Li; Ming Sun
Journal:  Neurochem Res       Date:  2014-04-02       Impact factor: 3.996

10.  Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes.

Authors:  Tatyana G Pekun; Sviatlana V Hrynevich; Tatyana V Waseem; Sergei V Fedorovich
Journal:  Springerplus       Date:  2014-09-26
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