Literature DB >> 20154668

The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Alex Berndt, Simon Miller, Olusegun Williams, Daniel D Le, Benjamin T Houseman, Joseph I Pacold, Fabrice Gorrec, Wai-Ching Hon, Yi Liu, Christian Rommel, Pascale Gaillard, Thomas Rückle, Matthias K Schwarz, Kevan M Shokat, Jeffrey P Shaw, Roger L Williams.   

Abstract

Entities:  

Year:  2010        PMID： 20154668     DOI： 10.1038/nchembio0310-244b

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  1 in total

1.  The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Authors:  Alex Berndt; Simon Miller; Olusegun Williams; Daniel D Le; Benjamin T Houseman; Joseph I Pacold; Fabrice Gorrec; Wai-Ching Hon; Yi Liu; Christian Rommel; Pascale Gaillard; Thomas Rückle; Matthias K Schwarz; Kevan M Shokat; Jeffrey P Shaw; Roger L Williams
Journal:  Nat Chem Biol       Date:  2010-02       Impact factor: 15.040
  1 in total
  14 in total

Review 1.  Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

Authors:  Paul Workman; Paul A Clarke; Florence I Raynaud; Rob L M van Montfort
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

2.  Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168).

Authors:  Marcian E Van Dort; Stefanie Galbán; Charles A Nino; Hao Hong; April A Apfelbaum; Gary D Luker; Greg M Thurber; Lydia Atangcho; Cagri G Besirli; Brian D Ross
Journal:  ACS Med Chem Lett       Date:  2017-07-24       Impact factor: 4.345

3.  2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study.

Authors:  Qianyi Chen; Vashti C Bryant; Hernando Lopez; David L Kelly; Xu Luo; Amarnath Natarajan
Journal:  Bioorg Med Chem Lett       Date:  2011-02-17       Impact factor: 2.823

Review 4.  PI3K and cancer: lessons, challenges and opportunities.

Authors:  David A Fruman; Christian Rommel
Journal:  Nat Rev Drug Discov       Date:  2014-02       Impact factor: 84.694

5.  Class I PI3K Biology.

Authors:  Tihitina Y Aytenfisu; Hannah M Campbell; Mayukh Chakrabarti; L Mario Amzel; Sandra B Gabelli
Journal:  Curr Top Microbiol Immunol       Date:  2022       Impact factor: 4.737

6.  Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects.

Authors:  Sandra B Gabelli; Ignacia Echeverria; Megan Alexander; Krisna C Duong-Ly; Daniele Chaves-Moreira; Evan T Brower; B Vogelstein; L Mario Amzel
Journal:  Biophys Rev       Date:  2014-03-01

7.  Interaction of Ras with p110γ is required for thymic β-selection in the mouse.

Authors:  Michelle L Janas; Martin Turner
Journal:  J Immunol       Date:  2011-09-19       Impact factor: 5.422

8.  Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα.

Authors:  Qiangjun Zhou; Jiangmei Li; Hang Yu; Yujia Zhai; Zhen Gao; Yanxin Liu; Xiaoyun Pang; Lunfeng Zhang; Klaus Schulten; Fei Sun; Chang Chen
Journal:  Nat Commun       Date:  2014-03-28       Impact factor: 14.919

9.  Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:  Ivan Angulo; Oscar Vadas; Fabien Garçon; Edward Banham-Hall; Vincent Plagnol; Timothy R Leahy; Helen Baxendale; Tanya Coulter; James Curtis; Changxin Wu; Katherine Blake-Palmer; Olga Perisic; Deborah Smyth; Mailis Maes; Christine Fiddler; Jatinder Juss; Deirdre Cilliers; Gašper Markelj; Anita Chandra; George Farmer; Anna Kielkowska; Jonathan Clark; Sven Kracker; Marianne Debré; Capucine Picard; Isabelle Pellier; Nada Jabado; James A Morris; Gabriela Barcenas-Morales; Alain Fischer; Len Stephens; Phillip Hawkins; Jeffrey C Barrett; Mario Abinun; Menna Clatworthy; Anne Durandy; Rainer Doffinger; Edwin R Chilvers; Andrew J Cant; Dinakantha Kumararatne; Klaus Okkenhaug; Roger L Williams; Alison Condliffe; Sergey Nejentsev
Journal:  Science       Date:  2013-10-17       Impact factor: 47.728

Review 10.  PI3K inhibitors are finally coming of age.

Authors:  Bart Vanhaesebroeck; Matthew W D Perry; Jennifer R Brown; Fabrice André; Klaus Okkenhaug
Journal:  Nat Rev Drug Discov       Date:  2021-06-14       Impact factor: 112.288
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