Martin Peter Grobusch1. 1. Division of Infectious Diseases, Department of Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa. martin.grobusch@wits.ac.za
Abstract
PURPOSE OF REVIEW: Drug-resistant tuberculosis (TB) is of increasing global concern. One of the hardest hit regions is southern Africa. This study focuses on a concise update on recently published developments in the field. RECENT FINDINGS: There is mounting evidence from high-coprevalence areas that the TB and HIV pandemics must be viewed as an entity and tackled together. In that context, it has become clear that a shift may be required from standard hospital-based models of care towards community-based approaches. Innovative rapid diagnostics to detect TB drug resistance suitable for the use in resource-poor settings and novel drugs effective against drug-resistant Mycobacterium tuberculosis strains are currently developed. SUMMARY: In order to allow for a maximum impact of novel interventions on the problem of multidrug-resistant and extensively drug-resistant TB, public health systems and existing TB programs must be strengthened significantly.
PURPOSE OF REVIEW: Drug-resistant tuberculosis (TB) is of increasing global concern. One of the hardest hit regions is southern Africa. This study focuses on a concise update on recently published developments in the field. RECENT FINDINGS: There is mounting evidence from high-coprevalence areas that the TB and HIV pandemics must be viewed as an entity and tackled together. In that context, it has become clear that a shift may be required from standard hospital-based models of care towards community-based approaches. Innovative rapid diagnostics to detect TB drug resistance suitable for the use in resource-poor settings and novel drugs effective against drug-resistant Mycobacterium tuberculosis strains are currently developed. SUMMARY: In order to allow for a maximum impact of novel interventions on the problem of multidrug-resistant and extensively drug-resistant TB, public health systems and existing TB programs must be strengthened significantly.
Authors: S Janssen; M A M Huson; S Bélard; S Stolp; N Kapata; M Bates; M van Vugt; M P Grobusch Journal: Infection Date: 2013-12-06 Impact factor: 3.553
Authors: A C Hesseling; S Kim; S Madhi; S Nachman; H S Schaaf; A Violari; T C Victor; G McSherry; C Mitchell; M F Cotton Journal: Int J Tuberc Lung Dis Date: 2012-02 Impact factor: 2.373
Authors: Saskia Janssen; Rajesh Jayachandran; Lulama Khathi; Jakob Zinsstag; Martin P Grobusch; Jean Pieters Journal: Drug Des Devel Ther Date: 2012-09-07 Impact factor: 4.162
Authors: Deliwe Nkosi; Saskia Janssen; Xavier Padanilam; Rianna Louw; Colin N Menezes; Martin P Grobusch Journal: BMC Health Serv Res Date: 2013-07-09 Impact factor: 2.655