Literature DB >> 20154202

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.

Colm M P O'Tuathaigh1, John L Waddington.   

Abstract

The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.

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Year:  2010        PMID: 20154202      PMCID: PMC2833133          DOI: 10.1093/schbul/sbq004

Source DB:  PubMed          Journal:  Schizophr Bull        ISSN: 0586-7614            Impact factor:   9.306


  8 in total

1.  Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.

Authors:  Nicole C Allen; Sachin Bagade; Matthew B McQueen; John P A Ioannidis; Fotini K Kavvoura; Muin J Khoury; Rudolph E Tanzi; Lars Bertram
Journal:  Nat Genet       Date:  2008-07       Impact factor: 38.330

Review 2.  What have the genomics ever done for the psychoses?

Authors:  M Gill; G Donohoe; A Corvin
Journal:  Psychol Med       Date:  2009-10-12       Impact factor: 7.723

Review 3.  The endophenotype concept in psychiatry: etymology and strategic intentions.

Authors:  Irving I Gottesman; Todd D Gould
Journal:  Am J Psychiatry       Date:  2003-04       Impact factor: 18.112

Review 4.  Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder.

Authors:  David L Braff; Robert Freedman; Nicholas J Schork; Irving I Gottesman
Journal:  Schizophr Bull       Date:  2006-11-06       Impact factor: 9.306

5.  Rare chromosomal deletions and duplications increase risk of schizophrenia.

Authors: 
Journal:  Nature       Date:  2008-07-30       Impact factor: 49.962

Review 6.  Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption.

Authors:  Brian P Kirby; John L Waddington; Colm M P O'Tuathaigh
Journal:  Brain Res Bull       Date:  2009-10-01       Impact factor: 4.077

Review 7.  Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?

Authors:  Lieve Desbonnet; John L Waddington; Colm M P O Tuathaigh
Journal:  Behav Brain Res       Date:  2009-12-07       Impact factor: 3.332

8.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

Authors:  Shaun M Purcell; Naomi R Wray; Jennifer L Stone; Peter M Visscher; Michael C O'Donovan; Patrick F Sullivan; Pamela Sklar
Journal:  Nature       Date:  2009-07-01       Impact factor: 49.962

  8 in total
  8 in total

1.  Effects of fingolimod administration in a genetic model of cognitive deficits.

Authors:  D Becker-Krail; A Q Farrand; H A Boger; A Lavin
Journal:  J Neurosci Res       Date:  2016-07-20       Impact factor: 4.164

Review 2.  Animal models of schizophrenia.

Authors:  C A Jones; D J G Watson; K C F Fone
Journal:  Br J Pharmacol       Date:  2011-10       Impact factor: 8.739

3.  Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats.

Authors:  John P Redrobe; Lisbeth Elster; Kristen Frederiksen; Christoffer Bundgaard; Inge E M de Jong; Garrick P Smith; Anne Techau Bruun; Peter H Larsen; Michael Didriksen
Journal:  Psychopharmacology (Berl)       Date:  2011-11-29       Impact factor: 4.530

4.  In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.

Authors:  John P Redrobe; Morten Jørgensen; Claus T Christoffersen; Liliana P Montezinho; Jesper F Bastlund; Martin Carnerup; Christoffer Bundgaard; Linda Lerdrup; Niels Plath
Journal:  Psychopharmacology (Berl)       Date:  2014-03-01       Impact factor: 4.530

5.  Disordered ripples are a common feature of genetically distinct mouse models relevant to schizophrenia.

Authors:  Cara Altimus; Jon Harrold; Hanna Jaaro-Peled; Akira Sawa; David J Foster
Journal:  Mol Neuropsychiatry       Date:  2015-05

Review 6.  Anhedonia, avolition, and anticipatory deficits: assessments in animals with relevance to the negative symptoms of schizophrenia.

Authors:  Samuel A Barnes; Andre Der-Avakian; Athina Markou
Journal:  Eur Neuropsychopharmacol       Date:  2013-10-14       Impact factor: 4.600

7.  Translational Aspects of the Novel Object Recognition Task in Rats Abstinent Following Sub-Chronic Treatment with Phencyclidine (PCP): Effects of Modafinil and Relevance to Cognitive Deficits in Schizophrenia.

Authors:  John P Redrobe; Sascha Bull; Niels Plath
Journal:  Front Psychiatry       Date:  2010-11-11       Impact factor: 4.157

8.  Serum levels of β-hydroxybutyrate and pyruvate, metabolic changes and cognitive function in patients with schizophrenia during antipsychotic treatment: a preliminary study.

Authors:  Chih-Ching Wu; Liang-Jen Wang; Yu-Chi Huang; Pao-Yen Lin; Yu Lee; Chi-Fa Hung; Su-Ting Hsu
Journal:  Neuropsychiatr Dis Treat       Date:  2018-03-19       Impact factor: 2.570

  8 in total

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