Literature DB >> 20153797

The secretome of a recombinant BCG substrain reveals differences in hypothetical proteins.

Mauricio Rodríguez-Alvarez1, Iliana D Palomec-Nava, Guillermo Mendoza-Hernández, Yolanda López-Vidal.   

Abstract

Tuberculosis remains a major human health problem worldwide, and strategies for its prevention include the generation and characterization of new recombinant vaccines containing immunodominant antigens from Mycobacterium tuberculosis. By comparing the secretomes of wild-type Mycobacterium bovis and a PstS1-recombinant M. bovis BCG vaccine substrain (rBCG38), we identified six conserved hypothetical proteins (BCG2696, BCG1674, BCG0372, BCG0427, BCG2436c, and BCG3053) that are differentially expressed. Our findings will aid in the identification of highly immunogenic proteins present in rBCG. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20153797     DOI： 10.1016/j.vaccine.2010.01.064

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  4 in total

1.  Analysis of the secretome and identification of novel constituents from culture filtrate of bacillus Calmette-Guerin using high-resolution mass spectrometry.

Authors:  Jianhua Zheng; Xianwen Ren; Candong Wei; Jian Yang; Yongfeng Hu; Liguo Liu; Xingye Xu; Jin Wang; Qi Jin
Journal:  Mol Cell Proteomics       Date:  2013-04-24       Impact factor: 5.911

2.  Genomic and proteomic analyses of Mycobacterium bovis BCG Mexico 1931 reveal a diverse immunogenic repertoire against tuberculosis infection.

Authors:  Patricia Orduña; Miguel A Cevallos; Samuel Ponce de León; Adriana Arvizu; Ismael L Hernández-González; Guillermo Mendoza-Hernández; Yolanda López-Vidal
Journal:  BMC Genomics       Date:  2011-10-08       Impact factor: 3.969

3.  Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur.

Authors:  Marcia Berrêdo-Pinho; Dario E Kalume; Paloma R Correa; Leonardo H F Gomes; Melissa P Pereira; Renata F da Silva; Luiz R R Castello-Branco; Wim M Degrave; Leila Mendonça-Lima
Journal:  BMC Microbiol       Date:  2011-04-20       Impact factor: 3.605

4.  Specific Proteins in Nontuberculous Mycobacteria: New Potential Tools.

Authors:  Patricia Orduña; Antonia I Castillo-Rodal; Martha E Mercado; Samuel Ponce de León; Yolanda López-Vidal
Journal:  Biomed Res Int       Date:  2015-05-28       Impact factor: 3.411
  4 in total

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