| Literature DB >> 20153645 |
Larry R McLean1, Ying Zhang, William Degnen, Jane Peppard, Dasha Cabel, Chao Zou, Joseph T Tsay, Arun Subramaniam, Roy J Vaz, Yi Li.
Abstract
Amino-benzoic acid derivatives 1-4 were found to be inhibitors for DHODH by virtual screening, biochemical, and X-ray crystallographic studies. X-ray structures showed that 1 and 2 bind to DHODH as predicted by virtual screening, but 3 and 4 were found to be structurally different from the corresponding compounds initially identified by virtual screening. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20153645 DOI： 10.1016/j.bmcl.2010.01.115
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823