| Literature DB >> 20153643 |
Diane H Boschelli1, Joan Subrath, Chuansheng Niu, Biqi Wu, Yan Wang, Julie Lee, Agnes Brennan, Melisa Ho, Bijia Deng, Xiaoke Yang, Xin Xu, Louis Leung, Jianyao Wang, James Atherton, Divya Chaudhary.
Abstract
Analog 8, a 3-pyridinecarbonitrile with an (E)-2-[6-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]vinyl group at C-5, had an IC(50) value of 1.1 nM for the inhibition of PKCtheta and potently blocked the production of IL-2 in both stimulated murine T cells (IC(50)=34 nM) and human whole blood (IC(50)=500 nM). Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20153643 DOI： 10.1016/j.bmcl.2010.01.119
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823