Literature DB >> 20153642

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

Dhimant Desai1, SubbaRao V Madhunapantula, Krishnegowda Gowdahalli, Arati Sharma, Raghavendragowda Chandagaludoreswamy, Karam El-Bayoumy, Gavin P Robertson, Shantu Amin.   

Abstract

Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents. Copyright 2010. Published by Elsevier Ltd.

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Year:  2009        PMID： 20153642      PMCID： PMC2892985          DOI： 10.1016/j.bmcl.2009.09.071

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  47 in total

1.  Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.

Authors:  C V Rao; T Kawamori; R Hamid; B S Reddy
Journal:  Carcinogenesis       Date:  1999-04       Impact factor: 4.944

2.  Effect of dietary supplementation of selenite on pulmonary metastasis of melanoma cells in mice.

Authors:  L Yan; J A Yee; M H McGuire; G L Graef
Journal:  Nutr Cancer       Date:  1997       Impact factor: 2.900

3.  Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

Authors:  T Kawamori; C V Rao; K Seibert; B S Reddy
Journal:  Cancer Res       Date:  1998-02-01       Impact factor: 12.701

4.  Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group.

Authors:  L C Clark; G F Combs; B W Turnbull; E H Slate; D K Chalker; J Chow; L S Davis; R A Glover; G F Graham; E G Gross; A Krongrad; J L Lesher; H K Park; B B Sanders; C L Smith; J R Taylor
Journal:  JAMA       Date:  1996-12-25       Impact factor: 56.272

5.  Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets.

Authors:  B S Reddy; A Rivenson; K El-Bayoumy; P Upadhyaya; B Pittman; C V Rao
Journal:  J Natl Cancer Inst       Date:  1997-04-02       Impact factor: 13.506

Review 6.  Nutrition and colorectal cancer.

Authors:  J D Potter
Journal:  Cancer Causes Control       Date:  1996-01       Impact factor: 2.506

7.  Chemoprevention of colon carcinogenesis by organosulfur compounds.

Authors:  B S Reddy; C V Rao; A Rivenson; G Kelloff
Journal:  Cancer Res       Date:  1993-08-01       Impact factor: 12.701

8.  Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

Authors:  B S Reddy; C V Rao; K Seibert
Journal:  Cancer Res       Date:  1996-10-15       Impact factor: 12.701

9.  Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.

Authors:  L C Clark; B Dalkin; A Krongrad; G F Combs; B W Turnbull; E H Slate; R Witherington; J H Herlong; E Janosko; D Carpenter; C Borosso; S Falk; J Rounder
Journal:  Br J Urol       Date:  1998-05

10.  Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

Authors:  E P Garvey; J A Oplinger; G J Tanoury; P A Sherman; M Fowler; S Marshall; M F Harmon; J E Paith; E S Furfine
Journal:  J Biol Chem       Date:  1994-10-28       Impact factor: 5.157
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  8 in total

1.  Melanoma prevention using topical PBISe.

Authors:  Chin-Ying Chung; SubbaRao V Madhunapantula; Dhimant Desai; Shantu Amin; Gavin P Robertson
Journal:  Cancer Prev Res (Phila)       Date:  2011-03-02

2.  Electrophilic aromatic selenylation: new OPRT inhibitors.

Authors:  Mohannad Abdo; Yong Zhang; Vern L Schramm; Spencer Knapp
Journal:  Org Lett       Date:  2010-07-02       Impact factor: 6.005

Review 3.  The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.

Authors:  SubbaRao V Madhunapantula; Paul J Mosca; Gavin P Robertson
Journal:  Cancer Biol Ther       Date:  2011-12-15       Impact factor: 4.742

4.  Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib.

Authors:  Dhimant Desai; Naveen Kaushal; Ujjawal H Gandhi; Ryan J Arner; Christopher D'Souza; Gang Chen; Hema Vunta; Karam El-Bayoumy; Shantu Amin; K Sandeep Prabhu
Journal:  Chem Biol Interact       Date:  2010-09-29       Impact factor: 5.192

5.  OGA inhibition by GlcNAc-selenazoline.

Authors:  Eun Ju Kim; Dona C Love; Etzer Darout; Mohannad Abdo; Brian Rempel; Stephen G Withers; Paul R Rablen; John A Hanover; Spencer Knapp
Journal:  Bioorg Med Chem       Date:  2010-08-11       Impact factor: 3.641

Review 6.  Chemoprevention of melanoma.

Authors:  Subbarao V Madhunapantula; Gavin P Robertson
Journal:  Adv Pharmacol       Date:  2012

7.  A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.

Authors:  Hephzibah Rani S Tagaram; Dhimant Desai; Guangfu Li; Dai Liu; C Bart Rountree; Kavitha Gowda; Arthur Berg; Shantu Amin; Kevin F Staveley-O'Carroll; Eric T Kimchi
Journal:  Pharmaceuticals (Basel)       Date:  2016-03-24

8.  Microwave-assisted synthesis of new selenazole derivatives with antiproliferative activity.

Authors:  Adriana Ignat Ignat Grozav; Luiza Gaina; Victor Kuete; Luminita Silaghi-Dumitrescu; Thomas Efferth; Valentin Zaharia
Journal:  Molecules       Date:  2013-04-19       Impact factor: 4.411
  8 in total

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