| Literature DB >> 20153564 |
T López1, F Figueras, J Manjarrez, J Bustos, M Alvarez, J Silvestre-Albero, F Rodríguez-Reinoso, A Martínez-Ferre, E Martínez.
Abstract
Novel nanostructured TiO2 and SiO2 based biocatalysts, with 3-4 wt. % of Pt have been developed. The obtained materials exhibit a high surface area together with a broad pore size distribution. The method of synthesis allowed obtaining high dispersed platinum metal nanoparticles. In vitro DNA reactivity test of the biocatalysts were carried out by electrophoresis and formation of DNA adducts was observed. The most active biocatalyst was H2PtCl6/SiO2. These biocatalysts were also tested in an experimental model of C6 brain tumours in Wistar rats. Administration of the material was made by stereotactic brain surgery to place it directly in the malignant tissue. A significant decrease in tumour size and weight as well as morphologic changes in cancer cells were observed. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2010 PMID： 20153564 DOI： 10.1016/j.ejmech.2010.01.043
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514