INTRODUCTION: Bordetella pertussis (whooping cough) is a worldwide public health problem. It is estimated that there are about 20 to 40 million cases with 200,000-400,000 deaths and is increasing in infants and adults. MATERIALS AND METHODS: An observational, retrospective study was made. We reviewed the epidemiologic surveillance notification forms from 2001 to 2008 period at the Epidemiology Department of Hospital Del Niño, a tertiary paediatric reference centre in Panama City. All pertussis (whooping cough) cases confirmed by PCR and cultures were selected. RESULTS: From a total of 759 notifications of suspected whooping cough cases, 180 confirmed cases using PCR and culture were analyzed for this study. The admission rate in all ages was 14.4/10,000 admissions, predominantly in < or =3 months with 42.76/10,000 admissions and which accounted for 75% of the cases. Cough was the most important symptom (91%). Cyanosis, leucocytosis and lymphocytosis were the most characteristic clinical findings when comparing positive pertussis with negative. More than two thirds of the subjects less than 3 months of age had not been vaccinated at the time of admission. The death rate was 8.3%, more than half of them in subjects less than 1 month of age. CONCLUSIONS: Whooping cough is an important public health problem. Post-partum vaccination could be a strategy to reduce morbidity and mortality in infants less than 3 months of age. 2009 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.
INTRODUCTION: Bordetella pertussis (whooping cough) is a worldwide public health problem. It is estimated that there are about 20 to 40 million cases with 200,000-400,000 deaths and is increasing in infants and adults. MATERIALS AND METHODS: An observational, retrospective study was made. We reviewed the epidemiologic surveillance notification forms from 2001 to 2008 period at the Epidemiology Department of Hospital Del Niño, a tertiary paediatric reference centre in Panama City. All pertussis (whooping cough) cases confirmed by PCR and cultures were selected. RESULTS: From a total of 759 notifications of suspected whooping cough cases, 180 confirmed cases using PCR and culture were analyzed for this study. The admission rate in all ages was 14.4/10,000 admissions, predominantly in < or =3 months with 42.76/10,000 admissions and which accounted for 75% of the cases. Cough was the most important symptom (91%). Cyanosis, leucocytosis and lymphocytosis were the most characteristic clinical findings when comparing positive pertussis with negative. More than two thirds of the subjects less than 3 months of age had not been vaccinated at the time of admission. The death rate was 8.3%, more than half of them in subjects less than 1 month of age. CONCLUSIONS: Whooping cough is an important public health problem. Post-partum vaccination could be a strategy to reduce morbidity and mortality in infants less than 3 months of age. 2009 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.
Authors: Varun K Phadke; John P McCracken; Jennifer L Kriss; Maria R Lopez; Kim A Lindblade; Joe P Bryan; Miguel E Garcia; Carlos E Funes; Saad B Omer Journal: J Pediatric Infect Dis Soc Date: 2018-12-03 Impact factor: 5.235
Authors: Ivana Pavic-Espinoza; Sandy Bendezú-Medina; Angella Herrera-Alzamora; Pablo Weilg; María J Pons; Miguel Angel Aguilar-Luis; Verónica Petrozzi-Helasvuo; Juana del Valle Mendoza Journal: BMC Infect Dis Date: 2015-12-02 Impact factor: 3.090