P Ewert1, H Bertram2, J Breuer3, I Dähnert4, S Dittrich5, A Eicken6, M Emmel7, G Fischer8, R Gitter9, M Gorenflo10, N Haas11, E Kitzmüller12, A Koch13, O Kretschmar14, A Lindinger15, I Michel-Behnke16, J H Nuernberg17, M Peuster11, K Walter18, P Zartner19, F Uhlemann20. 1. Deutsches Herzzentrum Berlin, Germany. Electronic address: ewert@dhzb.de. 2. Medizinische Hochschule Hannover, Germany. 3. Universitätsklinik Bonn, Germany. 4. Herzzentrum Leipzig, Germany. 5. Universitätsklinik Freiburg, Germany. 6. Deutsches Herzzentrum München, Germany. 7. Universitätsklinik Köln, Germany. 8. Universitätsklinik Kiel, Germany. 9. Landes-Kinderklinik Linz, Germany. 10. Universitätsklinik Heidelberg, Germany. 11. Herz- und Diabeteszentrum Nordrhein-Westfalen, Germany. 12. Universitätsklinik Wien, Austria. 13. Universitätsklinik Erlangen, Germany. 14. Kinderspital Zürich, Switzerland. 15. Universitätsklinik Homburg, Germany. 16. Universitätsklinik Giessen, Germany. 17. Klinikum Links der Weser, Bremen, Germany. 18. Herzzentrum Duisburg, Germany. 19. Deutsches Kinderherzzentrum St. Augustin, Germany. 20. Olgahospital Stuttgart, Germany.
Abstract
BACKGROUND: The value of balloon valvuloplasty of the aortic valve in childhood is still under debate. OBJECTIVE: To evaluate the results of the procedure in a retrospective multicenter survey of a large cohort over a long time interval. METHODS: Retrospective analysis of 1004 patients with balloon valvuloplasty of the aortic valve performed between 9/1985 and 10/2006 at 20 centers in Germany, Austria and Switzerland. Amongst others, the following parameters were evaluated before and after the procedure as well as at the end of follow-up or before surgery: clinical status, left ventricular function, transaortic pressure gradient, degree of aortic regurgitation, freedom from re-intervention or surgery. PATIENTS: Patients from 1 day to 18 years of age with aortic valve stenosis were divided into four groups: 334 newborns (1-28 days); 249 infants (29-365 days); 211 children (1-10 years), and 210 adolescents (10-18 years). RESULTS: Median follow-up was 32 months (0 days to 17.5 years). After dilatation the pressure gradient decreased from 65 (± 24)mm Hg to 26 (± 16)mm Hg and remained stable during follow-up. The newborns were the most affected patients. Approximately 60% of them had clinical symptoms and impaired left ventricular function before intervention. Complication rate was 15% in newborns, 11% in infants and 6% in older children. Independently of age, 50% of all patients were free from surgery 10 years after intervention. CONCLUSIONS: In this retrospective multicenter study, balloon valvuloplasty of the aortic valve has effectively postponed the need for surgery in infants, children and adolescents up to 18 years of age.
BACKGROUND: The value of balloon valvuloplasty of the aortic valve in childhood is still under debate. OBJECTIVE: To evaluate the results of the procedure in a retrospective multicenter survey of a large cohort over a long time interval. METHODS: Retrospective analysis of 1004 patients with balloon valvuloplasty of the aortic valve performed between 9/1985 and 10/2006 at 20 centers in Germany, Austria and Switzerland. Amongst others, the following parameters were evaluated before and after the procedure as well as at the end of follow-up or before surgery: clinical status, left ventricular function, transaortic pressure gradient, degree of aortic regurgitation, freedom from re-intervention or surgery. PATIENTS: Patients from 1 day to 18 years of age with aortic valve stenosis were divided into four groups: 334 newborns (1-28 days); 249 infants (29-365 days); 211 children (1-10 years), and 210 adolescents (10-18 years). RESULTS: Median follow-up was 32 months (0 days to 17.5 years). After dilatation the pressure gradient decreased from 65 (± 24)mm Hg to 26 (± 16)mm Hg and remained stable during follow-up. The newborns were the most affected patients. Approximately 60% of them had clinical symptoms and impaired left ventricular function before intervention. Complication rate was 15% in newborns, 11% in infants and 6% in older children. Independently of age, 50% of all patients were free from surgery 10 years after intervention. CONCLUSIONS: In this retrospective multicenter study, balloon valvuloplasty of the aortic valve has effectively postponed the need for surgery in infants, children and adolescents up to 18 years of age.
Authors: Sergej M Prijic; Vladislav A Vukomanovic; Mila S Stajevic; Bojko B Bjelakovic; Marija D Zdravkovic; Igor N Sehic; Jovan Lj Kosutic Journal: Pediatr Cardiol Date: 2014-11-12 Impact factor: 1.655
Authors: Anna Olasińska-Wiśniewska; Olga Trojnarska; Marek Grygier; Maciej Lesiak; Stefan Grajek Journal: Postepy Kardiol Interwencyjnej Date: 2013-03-21 Impact factor: 1.426