OBJECTIVE: To evaluate the feasibility and performance of screening for cervical cancer using visual inspection with acetic acid (VIA) or with Lugol's iodine (VILI) in Dar es Salaam, Tanzania. METHODS: The accuracy of tests for detecting cervical intraepithelial neoplasia (CIN) was assessed in a cross-sectional study of 10378 women. All women who were screened underwent colposcopy, and biopsies were offered to those with abnormal colposcopy results. RESULTS: The positivity rates were 3.8% for VIA and 4.8% for VILI. The peak positivity rates for both visual tests were observed just after training or re-training and gradually declined thereafter. CIN 1 was diagnosed in 41 women, CIN 2-3 in 33 women, and invasive cancer in 200 women, showing high detection rates of invasive cancer. The sensitivity and specificity for the detection of CIN 2-3 lesions were 60.6% (95% confidence interval [CI], 42.1-77.1) and 98.2% (95% CI, 97.9-98.4), respectively, for VIA; and 93.9% (95% CI, 79.8-99.3) and 97.3% (95% CI, 97.0-97.6), respectively, for VILI. Two-thirds of the women detected with CIN 2-3 lesions were treated. CONCLUSION: Both visual screening tests are useful and accurate, especially in low-income settings. Standardization of assessment of the visual inspection techniques, continual training and supervision, and quality control measures are important for successful visual screening programs. Copyright 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
OBJECTIVE: To evaluate the feasibility and performance of screening for cervical cancer using visual inspection with acetic acid (VIA) or with Lugol's iodine (VILI) in Dar es Salaam, Tanzania. METHODS: The accuracy of tests for detecting cervical intraepithelial neoplasia (CIN) was assessed in a cross-sectional study of 10378 women. All women who were screened underwent colposcopy, and biopsies were offered to those with abnormal colposcopy results. RESULTS: The positivity rates were 3.8% for VIA and 4.8% for VILI. The peak positivity rates for both visual tests were observed just after training or re-training and gradually declined thereafter. CIN 1 was diagnosed in 41 women, CIN 2-3 in 33 women, and invasive cancer in 200 women, showing high detection rates of invasive cancer. The sensitivity and specificity for the detection of CIN 2-3 lesions were 60.6% (95% confidence interval [CI], 42.1-77.1) and 98.2% (95% CI, 97.9-98.4), respectively, for VIA; and 93.9% (95% CI, 79.8-99.3) and 97.3% (95% CI, 97.0-97.6), respectively, for VILI. Two-thirds of the women detected with CIN 2-3 lesions were treated. CONCLUSION: Both visual screening tests are useful and accurate, especially in low-income settings. Standardization of assessment of the visual inspection techniques, continual training and supervision, and quality control measures are important for successful visual screening programs. Copyright 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors: Mercy Nyamewaa Asiedu; Anish Simhal; Usamah Chaudhary; Jenna L Mueller; Christopher T Lam; John W Schmitt; Gino Venegas; Guillermo Sapiro; Nimmi Ramanujam Journal: IEEE Trans Biomed Eng Date: 2018-12-18 Impact factor: 4.538
Authors: Renicha McCree; Mary Rose Giattas; Vikrant V Sahasrabuddhe; Pauline E Jolly; Michelle Y Martin; Stuart Lawrence Usdan; Connie Kohler; Nedra Lisovicz Journal: Oncologist Date: 2015-04-29
Authors: Alaya Koneru; Pauline E Jolly; Shaundra Blakemore; Renicha McCree; Nedra F Lisovicz; Eric A Aris; Thereza Mtesigwa; Safina Yuma; Julius D Mwaiselage Journal: Int J Gynaecol Obstet Date: 2017-05-02 Impact factor: 3.561
Authors: Lindsey J Mattick; Heather M Ochs-Balcom; Julius Mwaiselage; Crispin Kahesa; Andrew C Gard; Fatma Shalan; Amr S Soliman Journal: Cancer Causes Control Date: 2021-02-09 Impact factor: 2.506
Authors: J N I Vet; J L Kooijman; F C Henderson; F M Aziz; G Purwoto; H Susanto; I G D Surya; S Budiningsih; S Cornain; G J Fleuren; J B Trimbos; A A W Peters Journal: Br J Cancer Date: 2012-07-31 Impact factor: 7.640