BACKGROUND: The aim of this study was to test the impact of posterolateral myocardial systolic function on response to cardiac resynchronization therapy (CRT). METHODS: Forty patients were studied before and 4 +/- 2 months after CRT. Dyssynchrony was defined as anteroseptal wall-to-posterior wall delay (> or = 130 ms) caused by speckle-tracking radial strain. The average longitudinal strain in 4 posterior and lateral segments (epsilon-pl) in which the left ventricular pacing lead was positioned was calculated by automated functional imaging. Response to CRT was defined as a > or = 15% decrease in end-systolic volume. RESULTS: The negative value of epsilon-pl in responders was significantly higher than that in nonresponders at baseline (-7.8 +/- 6.9% vs -2.1 +/- 4.9%, P < .01). Combining dyssynchrony with epsilon-pl < -7.8% was more effective for predicting response to CRT than dyssynchrony parameters alone (92% vs 75%). CONCLUSION: The addition of posterolateral myocardial systolic function to the measurement of dyssynchrony appears to be of value for predicting response to CRT. Copyright 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
BACKGROUND: The aim of this study was to test the impact of posterolateral myocardial systolic function on response to cardiac resynchronization therapy (CRT). METHODS: Forty patients were studied before and 4 +/- 2 months after CRT. Dyssynchrony was defined as anteroseptal wall-to-posterior wall delay (> or = 130 ms) caused by speckle-tracking radial strain. The average longitudinal strain in 4 posterior and lateral segments (epsilon-pl) in which the left ventricular pacing lead was positioned was calculated by automated functional imaging. Response to CRT was defined as a > or = 15% decrease in end-systolic volume. RESULTS: The negative value of epsilon-pl in responders was significantly higher than that in nonresponders at baseline (-7.8 +/- 6.9% vs -2.1 +/- 4.9%, P < .01). Combining dyssynchrony with epsilon-pl < -7.8% was more effective for predicting response to CRT than dyssynchrony parameters alone (92% vs 75%). CONCLUSION: The addition of posterolateral myocardial systolic function to the measurement of dyssynchrony appears to be of value for predicting response to CRT. Copyright 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
Authors: Naomi D Herz; Joseph Engeda; Robbert Zusterzeel; William E Sanders; Kathryn M O'Callaghan; David G Strauss; Samantha B Jacobs; Kimberly A Selzman; Ileana L Piña; Daniel A Caños Journal: J Womens Health (Larchmt) Date: 2015-03-20 Impact factor: 2.681
Authors: Yanli Zhou; Tracy L Faber; Zenic Patel; Russell D Folks; Alice A Cheung; Ernest V Garcia; Prem Soman; Dianfu Li; Kejiang Cao; Ji Chen Journal: Nucl Med Commun Date: 2013-02 Impact factor: 1.690