| Literature DB >> 2015173 |
A Herchuelz1, D Gangji, F Derenne, J P Jeanniot, J Douchamps.
Abstract
1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine.Entities:
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Year: 1991 PMID： 2015173 PMCID： PMC1368414 DOI： 10.1111/j.1365-2125.1991.tb03859.x
Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335