Literature DB >> 20151333

Quantitative differences in intervertebral disc-matrix composition with age-related degeneration.

Hideki Murakami1, Tim S Yoon, Emad S Attallah-Wasif, Chaiwat Kraiwattanapong, Ichiro Kikkawa, William C Hutton.   

Abstract

This study was carried out to determine the effect of age on the intervertebral disc, using a rabbit model. Anulus fibrosus and nucleus pulposus tissue from New Zealand white rabbits aged 3 years old (old rabbits) and 6 months old (young rabbits) were used. The water content, the proteoglycan, the DNA content, and the mRNA levels of aggrecan, type I collagen, and type II collagen were all measured for each sample. Water, proteoglycan, DNA, and the mRNA levels of aggrecan and type II collagen were all greater in the nucleus pulposus of the young rabbits as compared to the old. For the anulus fibrosus, the difference between young and old is less marked with only proteoglycan and DNA being greater in the young disc as compared to the old. Clearly, according to our results, it is the nucleus pulposus that suffers the brunt of the changes with age.

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Year:  2010        PMID： 20151333     DOI： 10.1007/s11517-010-0586-1

Source DB:  PubMed          Journal:  Med Biol Eng Comput        ISSN： 0140-0118            Impact factor:   2.602


  19 in total

1.  Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science.

Authors:  Norbert Boos; Sabine Weissbach; Helmut Rohrbach; Christoph Weiler; Kevin F Spratt; Andreas G Nerlich
Journal:  Spine (Phila Pa 1976)       Date:  2002-12-01       Impact factor: 3.468

2.  Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration.

Authors:  Gabriella Cs-Szabo; Deborah Ragasa-San Juan; Vani Turumella; Koichi Masuda; Eugene J-M A Thonar; Howard S An
Journal:  Spine (Phila Pa 1976)       Date:  2002-10-15       Impact factor: 3.468

3.  1991 Volvo Award in basic sciences. Collagen types around the cells of the intervertebral disc and cartilage end plate: an immunolocalization study.

Authors:  S Roberts; J Menage; V Duance; S Wotton; S Ayad
Journal:  Spine (Phila Pa 1976)       Date:  1991-09       Impact factor: 3.468

4.  The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.

Authors:  J Antoniou; T Steffen; F Nelson; N Winterbottom; A P Hollander; R A Poole; M Aebi; M Alini
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

5.  Immunolocalization of major interstitial collagen types in human lumbar intervertebral discs of various ages.

Authors:  A G Nerlich; N Boos; I Wiest; M Aebi
Journal:  Virchows Arch       Date:  1998-01       Impact factor: 4.064

6.  Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls.

Authors:  H E Gruber; E N Hanley
Journal:  Spine (Phila Pa 1976)       Date:  1998-04-01       Impact factor: 3.468

7.  Fluorometric assay of DNA in cartilage explants using Hoechst 33258.

Authors:  Y J Kim; R L Sah; J Y Doong; A J Grodzinsky
Journal:  Anal Biochem       Date:  1988-10       Impact factor: 3.365

8.  Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression.

Authors:  Gwendolyn Sowa; Gianluca Vadalà; Rebecca Studer; John Kompel; Christina Iucu; Helga Georgescu; Lars Gilbertson; James Kang
Journal:  Spine (Phila Pa 1976)       Date:  2008-08-01       Impact factor: 3.468

Review 9.  Collagens, elastin and noncollagenous protein of the intervertebral disk.

Authors:  P Ghosh; G R Bushell; T F Taylor; W H Akeson
Journal:  Clin Orthop Relat Res       Date:  1977 Nov-Dec       Impact factor: 4.176

10.  Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc.

Authors:  Kern Singh; Koichi Masuda; Eugene J-M A Thonar; Howard S An; Gabriella Cs-Szabo
Journal:  Spine (Phila Pa 1976)       Date:  2009-01-01       Impact factor: 3.468
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  7 in total

1.  Region-media coupling in characterization and modelling of the disc annulus single lamella swelling.

Authors:  Javad Tavakoli
Journal:  Med Biol Eng Comput       Date:  2017-01-02       Impact factor: 2.602

Review 2.  Biomechanics of intervertebral disk degeneration.

Authors:  Nozomu Inoue; Alejandro A Espinoza Orías
Journal:  Orthop Clin North Am       Date:  2011-10       Impact factor: 2.472

3.  Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting.

Authors:  Makarand V Risbud; Zachary R Schoepflin; Fackson Mwale; Rita A Kandel; Sibylle Grad; James C Iatridis; Daisuke Sakai; Judith A Hoyland
Journal:  J Orthop Res       Date:  2015-01-21       Impact factor: 3.494

4.  Feasibility of MR elastography of the intervertebral disc.

Authors:  Ephraim I Ben-Abraham; Jun Chen; Joel P Felmlee; Phil Rossman; Armando Manduca; Kai-Nan An; Richard L Ehman
Journal:  Magn Reson Imaging       Date:  2015-12-30       Impact factor: 2.546

5.  Characterization of the age-dependent intervertebral disc changes in rabbit by correlation between MRI, histology and gene expression.

Authors:  Johann Clouet; Marianne Pot-Vaucel; Gaël Grimandi; Martial Masson; Julie Lesoeur; Borhane H Fellah; Olivier Gauthier; Marion Fusellier; Yan Cherel; Yves Maugars; Jérôme Guicheux; Claire Vinatier
Journal:  BMC Musculoskelet Disord       Date:  2011-07-04       Impact factor: 2.362

6.  Disk injury in patients with vertebral fractures-a prospective diagnostic accuracy study using dual-energy computed tomography.

Authors:  Matthias Pumberger; Michael Fuchs; Nils Engelhard; Kay Geert Hermann; Michael Putzier; Marcus R Makowski; Bernd Hamm; Torsten Diekhoff
Journal:  Eur Radiol       Date:  2019-01-16       Impact factor: 5.315

7.  Biomechanical changes of degenerated adjacent segment and intact lumbar spine after lumbosacral topping-off surgery: a three-dimensional finite element analysis.

Authors:  Liangliang Cao; Yumei Liu; Wei Mei; Jianguang Xu; Shi Zhan
Journal:  BMC Musculoskelet Disord       Date:  2020-02-15       Impact factor: 2.362
  7 in total

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