Tobias Bölling1, Normann Willich, Iris Ernst. 1. Department of Radiotherapy, University Hospital Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany. Tobias.Boelling@ukmuenster.de
Abstract
AIM: To comprehensively summarize the most important literature regarding the late effects of radiotherapy to the abdomen in childhood and adolescence. MATERIALS AND METHODS: Published trials, studies and series were identified using the PubMed database. The key words late effects, late sequelae, child, radiation, radiotherapy, abdomen, kidney, liver, and bowel were used. RESULTS: A dose-volume effect is confirmed for liver irradiation. Radiation with doses <20 Gy to major parts of the liver or higher doses to smaller parts seems to be safe. Kidney function impairment due to radiation is rare in children. Renal sequelae may occur after radiation to the remaining kidney in patients who underwent nephrectomy or who received higher doses to both kidneys. Several reports describe small bowel obstruction as a sequelae of surgery, but radiotherapy seems to be less important. CONCLUSION: Several retrospective reports describe radiation-associated late sequelae in children. However, there is still a lack of sufficient data regarding the characterization of dose-volume effects.
AIM: To comprehensively summarize the most important literature regarding the late effects of radiotherapy to the abdomen in childhood and adolescence. MATERIALS AND METHODS: Published trials, studies and series were identified using the PubMed database. The key words late effects, late sequelae, child, radiation, radiotherapy, abdomen, kidney, liver, and bowel were used. RESULTS: A dose-volume effect is confirmed for liver irradiation. Radiation with doses <20 Gy to major parts of the liver or higher doses to smaller parts seems to be safe. Kidney function impairment due to radiation is rare in children. Renal sequelae may occur after radiation to the remaining kidney in patients who underwent nephrectomy or who received higher doses to both kidneys. Several reports describe small bowel obstruction as a sequelae of surgery, but radiotherapy seems to be less important. CONCLUSION: Several retrospective reports describe radiation-associated late sequelae in children. However, there is still a lack of sufficient data regarding the characterization of dose-volume effects.
Authors: Robert Goldsby; Yan Chen; Shannon Raber; Linda Li; Karen Diefenbach; Margarett Shnorhavorian; Nina Kadan-Lottick; Fay Kastrinos; Yutaka Yasui; Marilyn Stovall; Kevin Oeffinger; Charles Sklar; Gregory T Armstrong; Leslie L Robison; Lisa Diller Journal: Gastroenterology Date: 2011-03-17 Impact factor: 22.682
Authors: Kevin X Liu; Natalie B Collins; Katie A Greenzang; Elissa Furutani; Kevin Campbell; Andrew Groves; Elizabeth A Mullen; Suzanne Shusterman; Jennifer Spidle; Karen J Marcus; Brent R Weil; Christopher B Weldon; A Lindsay Frazier; Katherine A Janeway; Allison F O'Neill; Jennifer W Mack; Steven G DuBois; David S Shulman Journal: Pediatr Blood Cancer Date: 2020-07-19 Impact factor: 3.167
Authors: Atmaram S Pai Panandiker; Shelly Sharma; Mihir H Naik; Shengjie Wu; Chiaho Hua; Chris Beltran; Matthew J Krasin; Thomas E Merchant Journal: Int J Radiat Oncol Biol Phys Date: 2011-05-27 Impact factor: 7.038
Authors: Arin L Madenci; Bryan V Dieffenbach; Qi Liu; Daisuke Yoneoka; Jamie Knell; Todd M Gibson; Yutaka Yasui; Wendy M Leisenring; Rebecca M Howell; Lisa R Diller; Kevin R Krull; Gregory T Armstrong; Kevin C Oeffinger; Andrew J Murphy; Brent R Weil; Christopher B Weldon Journal: Cancer Date: 2019-07-19 Impact factor: 6.860
Authors: Kenneth W Gow; Douglas C Barnhart; Thomas E Hamilton; Jessica J Kandel; Mike K S Chen; Fernando A Ferrer; Mitchell R Price; Elizabeth A Mullen; James I Geller; Eric J Gratias; Nancy Rosen; Geetika Khanna; Arlene Naranjo; Michael L Ritchey; Paul E Grundy; Jeffrey S Dome; Peter F Ehrlich Journal: J Pediatr Surg Date: 2013-01 Impact factor: 2.545
Authors: Arin L Madenci; Stacey Fisher; Lisa R Diller; Robert E Goldsby; Wendy M Leisenring; Kevin C Oeffinger; Leslie L Robison; Charles A Sklar; Marilyn Stovall; Rita E Weathers; Gregory T Armstrong; Yutaka Yasui; Christopher B Weldon Journal: J Clin Oncol Date: 2015-08-10 Impact factor: 44.544
Authors: Jinsoo Uh; Matthew J Krasin; Yimei Li; Xingyu Li; Christopher Tinkle; John T Lucas; Thomas E Merchant; Chiaho Hua Journal: Int J Radiat Oncol Biol Phys Date: 2017-05-25 Impact factor: 8.013