D M Sforza1, C M Putman, E Scrivano, P Lylyk, J R Cebral. 1. Department of Computational and Data Sciences, Center for Computational Fluid Dynamics, George Mason University, 4400 University Drive, Fairfax, VA 22030, USA.
Abstract
BACKGROUND AND PURPOSE: The development and validation of methods to stratify the risk of rupture of cerebral aneurysms is highly desired because current treatment risks can exceed the natural risk of rupture. Because unruptured aneurysms are typically treated before they rupture, it is very difficult to connect the proposed risk indices to the rupture of an individual aneurysm. The purpose of this case study was to analyze the hemodynamic environment of a saccular aneurysm of the terminal morphology subtype that was imaged just before its rupture and to test whether the hemodynamic characteristics would designate this particular aneurysm as at high risk. MATERIALS AND METHODS: A patient-specific CFD model was constructed from 3DRA images acquired just hours before the aneurysm ruptured. A pulsatile flow calculation was performed, and hemodynamic characteristics previously connected to rupture were analyzed. RESULTS: It was found that the aneurysm had a concentrated inflow stream, small impingement region, complex intra-aneurysmal flow structure, asymmetric flow split from the parent vessel to the aneurysm and daughter branches, and high levels of aneurysmal WSS near the impaction zone. CONCLUSIONS: The hemodynamic characteristics observed in this aneurysm right before its rupture are consistent with previous studies correlating aneurysm rupture and hemodynamic patterns in saccular and terminal aneurysms. This study supports the notion that hemodynamic information may be used to help stratify the rupture risk of cerebral aneurysms.
BACKGROUND AND PURPOSE: The development and validation of methods to stratify the risk of rupture of cerebral aneurysms is highly desired because current treatment risks can exceed the natural risk of rupture. Because unruptured aneurysms are typically treated before they rupture, it is very difficult to connect the proposed risk indices to the rupture of an individual aneurysm. The purpose of this case study was to analyze the hemodynamic environment of a saccular aneurysm of the terminal morphology subtype that was imaged just before its rupture and to test whether the hemodynamic characteristics would designate this particular aneurysm as at high risk. MATERIALS AND METHODS: A patient-specific CFD model was constructed from 3DRA images acquired just hours before the aneurysm ruptured. A pulsatile flow calculation was performed, and hemodynamic characteristics previously connected to rupture were analyzed. RESULTS: It was found that the aneurysm had a concentrated inflow stream, small impingement region, complex intra-aneurysmal flow structure, asymmetric flow split from the parent vessel to the aneurysm and daughter branches, and high levels of aneurysmal WSS near the impaction zone. CONCLUSIONS: The hemodynamic characteristics observed in this aneurysm right before its rupture are consistent with previous studies correlating aneurysm rupture and hemodynamic patterns in saccular and terminal aneurysms. This study supports the notion that hemodynamic information may be used to help stratify the rupture risk of cerebral aneurysms.
Authors: H Ujiie; H Tachibana; O Hiramatsu; A L Hazel; T Matsumoto; Y Ogasawara; H Nakajima; T Hori; K Takakura; F Kajiya Journal: Neurosurgery Date: 1999-07 Impact factor: 4.654
Authors: Christof Karmonik; Y Jonathan Zhang; Orlando Diaz; Richard Klucznik; Sasan Partovi; Robert G Grossman; Gavin W Britz Journal: Cardiovasc Diagn Ther Date: 2014-04
Authors: Jr Cebral; F Mut; D Sforza; R Löhner; E Scrivano; P Lylyk; Cm Putman Journal: Int J Numer Method Biomed Eng Date: 2011-07 Impact factor: 2.747