Literature DB >> 20150222

Relative biological effectiveness and cell-killing efficacy of continuous low-dose-rate 125I seeds on prostate carcinoma cells in vitro.

Anyan Liao1, Junjie Wang, Jidong Wang, Hongqing Zhuang, Yong Zhao.   

Abstract

The aim of this study was to determine the effects of (125)I seeds on prostate carcinoma (PC3) cells. The relative biological effectiveness of (125)I seeds on PC3 cells with respect to (60)Co gamma rays was 1.4. Both 4 Gy of (60)Co gamma ray and (125)I seed irradiation increased the percentage of cells in G(2) phase, but there was no significant difference between these 2 types of radiation. Significantly, (125)I seeds induced higher apoptotic rates of PC3 cells compared with (60)Co gamma ray irradiation. Furthermore, Bcl-2 expression, but not caspase-3 activity, in PC3 cells was downregulated after irradiation with (125)I seed or (60)Co gamma rays.

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Year:  2010        PMID： 20150222     DOI： 10.1177/1534735409357758

Source DB:  PubMed          Journal:  Integr Cancer Ther        ISSN： 1534-7354            Impact factor:   3.279


  7 in total

1.  Trans-bronchoscopy with implantation of 125I radioactive seeds in patients with pulmonary atelectasis induced by lung cancer.

Authors:  Mingjian Lu; Deli Pu; Weidong Zhang; Jiangrong Liao; Tao Zhang; Guang Yang; Zhenyin Liu; Sristi Singh; Fei Gao; Fujun Zhang
Journal:  Oncol Lett       Date:  2015-05-13       Impact factor: 2.967

2.  Computed tomography-guided implantation of 125I radioactive seeds in patients with malignant airway compression induced by advanced lung cancer: effectiveness and safety in 40 patients.

Authors:  Zhiyou Zhao; Wang Yao; Tao Zhang; Shixin Chen; Wei Fu; Lijun Chen; Yonggang Ma; Jianzhuang Wang; Mingjian Lu; Dechao Jiao
Journal:  J Contemp Brachytherapy       Date:  2020-08-21

3.  Preventive effects of ¹²⁵I seeds on benign restenosis following esophageal stent implantation in a dog model.

Authors:  Zhen Gan; Jian Jing; Guangyu Zhu; Yonglin Qin; Gaojun Teng; Jinhe Guo
Journal:  Mol Med Rep       Date:  2014-12-22       Impact factor: 2.952

4.  Radioactive (125)I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway.

Authors:  Yunhong Tian; Qiang Xie; Jie He; Xiaojun Luo; Tao Zhou; Ying Liu; Zuoping Huang; Yunming Tian; Dan Sun; Kaitai Yao
Journal:  BMC Cancer       Date:  2015-02-19       Impact factor: 4.430

5.  A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.

Authors:  Zhongmin Wang; Zhenzhen Zhao; Jian Lu; Zhijin Chen; Aiwu Mao; Gaojun Teng; Fenju Liu
Journal:  PLoS One       Date:  2015-08-12       Impact factor: 3.240

6.  Radioactive ¹²⁵I seed inhibits the cell growth, migration, and invasion of nasopharyngeal carcinoma by triggering DNA damage and inactivating VEGF-A/ERK signaling.

Authors:  Yunhong Tian; Qiang Xie; Yunming Tian; Ying Liu; Zuoping Huang; Cundong Fan; Bing Hou; Dan Sun; Kaitai Yao; Tianfeng Chen
Journal:  PLoS One       Date:  2013-09-10       Impact factor: 3.240

7.  The different biological effects of single, fractionated and continuous low dose rate irradiation on CL187 colorectal cancer cells.

Authors:  Hao Wang; Jinna Li; Ang Qu; Jingjia Liu; Yong Zhao; Junjie Wang
Journal:  Radiat Oncol       Date:  2013-08-09       Impact factor: 3.481
  7 in total

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