Literature DB >> 2014977

Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells.

J Szebeni1, S S Patel, K Hung, L M Wahl, J N Weinstein.   

Abstract

The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed [3H]AZT phosphorylation in the same concentration range (20 to 100 microM) in which it antagonizes the anti-human immunodeficiency virus activity of AZT. Uridine, in turn, had no influence on AZT phosphorylation, just as it has no effect on the anti-human immunodeficiency virus activity of AZT. These findings are consistent with a close relationship between the inhibition of AZT phosphorylation and the influence of physiological nucleosides on the antiviral activity of AZT.

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Year:  1991        PMID： 2014977      PMCID： PMC244969          DOI： 10.1128/AAC.35.1.198

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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4.  Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). I. Characterization of B-lymphocyte-, T-lymphocyte-, and monocyte-enriched fractions by flow cytometric analysis.

Authors:  L M Wahl; I M Katona; R L Wilder; C C Winter; B Haraoui; I Scher; S M Wahl
Journal:  Cell Immunol       Date:  1984-05       Impact factor: 4.868

5.  Deoxycytidine excretion by mouse peritoneal macrophages: its implication in modulation of immunological functions.

Authors:  T S Chan; B D Lakhchaura
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6.  3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

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7.  Production of the effector molecule thymidine by human lung alveolar macrophages.

Authors:  A Vercammen-Grandjean; R Arnould; A Libert; P Ewalenko; F Lejeune
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8.  Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Authors:  P A Furman; J A Fyfe; M H St Clair; K Weinhold; J L Rideout; G A Freeman; S N Lehrman; D P Bolognesi; S Broder; H Mitsuya
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

9.  Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages.

Authors:  D D Richman; R S Kornbluth; D A Carson
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  6 in total

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Review 2.  Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.

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Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

3.  Drug interactions with zidovudine phosphorylation in vitro.

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5.  Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages.

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Review 6.  Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases.

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  6 in total

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