| Literature DB >> 20149626 |
Valeriya Zarkhin1, Geetha Chalasani, Minnie M Sarwal.
Abstract
Various lineages of B cells are being increasingly recognized as important players in the etiology and prognosis of both acute and chronic graft rejection. The role of immature, chronically activated B cells, as efficient antigen-presenting cells, supporting recalcitrant cell-mediated graft rejection and late lineage B cells driving humoral rejections, is being increasingly recognized. This review captures the recent literature on this subject and discusses the various roles of the B cell in renal graft rejection and conversely, also in graft tolerance, both in animal and human studies. In addition, novel therapies targeting specific B-cell lineages in graft rejection are also discussed, with a view to developing more targeted therapies for graft rejection. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20149626 DOI： 10.1016/j.trre.2010.01.004
Source DB: PubMed Journal: Transplant Rev (Orlando) ISSN： 0955-470X Impact factor: 3.943