| Literature DB >> 20149498 |
Woo Duck Seo1, Young Bae Ryu, Marcus J Curtis-Long, Chan Woo Lee, Hyung Won Ryu, Ki Chang Jang, Ki Hun Park.
Abstract
The 4'-(p-toluenesulfonylamino)-4-hydroxychalcone (TSAHC), which bears inhibitory chemotypes for both alpha-glucosidase and tyrosinase, was evaluated for tyrosinase activity and depigmenting ability relative to compounds designed to only target tyrosianse activity. TSAHC emerged to be a competitive reversible inhibitor of mushroom tyrosinase. More importantly, it was also able to return the melanin content of alpha-melanocyte stimulated by alpha-MSH to base levels unlike other inhibitors that only targeted tyrosinase. The Western blot for expression levels of proteins involved in melanogenesis showed that TSAHC significantly decreased three main tyrosinase related protein in melanin biosynthesis, tyrosinase, TRP-1 and TRP-2. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20149498 DOI： 10.1016/j.ejmech.2010.01.049
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514