Literature DB >> 20148592

N-heterocyclic carbene-amine Pt(II) complexes, a new chemical space for the development of platinum-based anticancer drugs.

Myriem Skander1, Pascal Retailleau, Bernard Bourrié, Laurent Schio, Patrick Mailliet, Angela Marinetti.   

Abstract

N-Heterocyclic carbene (NHC) platinum complexes have been highlighted as a promising and original platform for building new cytotoxic drugs of the cisplatin series. Mixed NHC-amine Pt(II) complexes have been prepared via a facile and modular two step sequence leading to trans-configured square planar species. They have been characterized by spectroscopic methods and X-ray diffraction studies. Their efficiency against both cisplatin sensitive (CEM and H460) and resistant (A2780/DDP, CH1/DDP, and SK-OV-3) cell lines has been demonstrated by in vitro experiments.

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Year:  2010        PMID： 20148592     DOI： 10.1021/jm901693m

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor Agent.

Authors:  Leigh A Graham; Gary M Wilson; Tiffany K West; Cynthia S Day; Gregory L Kucera; Ulrich Bierbach
Journal:  ACS Med Chem Lett       Date:  2011-09-08       Impact factor: 4.345

2.  N-Heterocyclic Carbene Complexes of Nickel(II) from Caffeine and Theophylline: Sustainable Alternative to Imidazol-2-ylidenes.

Authors:  Jin Zhang; Mahbubur Rahman; Qun Zhao; Jessica Feliciano; Elwira Bisz; Błażej Dziuk; Roger Lalancette; Roman Szostak; Michal Szostak
Journal:  Organometallics       Date:  2022-04-05       Impact factor: 3.837

3.  Novel triplet germylenes in focus: normal vs. abnormal triplet exocyclic tetrazol-5-vinylidene germylenes at DFT.

Authors:  Samaneh Ashenagar; Mohamad Zaman Kassaee; Peter T Cummings
Journal:  J Mol Model       Date:  2019-12-02       Impact factor: 1.810

4.  Insight towards Nucleation Mechanism and Change in Morphology for Nanostructured Platinum Thin Film Directly Grown on Carbon Substrate via Electrochemical Deposition.

Authors:  Prabhakaran Dhanasekaran; Swaminathan Rajavarman; Sivasuriyanarayanan Vinod Selvaganesh; Santoshkumar Dattatray Bhat
Journal:  Materials (Basel)       Date:  2021-04-30       Impact factor: 3.623

Review 5.  Organometallic anticancer compounds.

Authors:  Gilles Gasser; Ingo Ott; Nils Metzler-Nolte
Journal:  J Med Chem       Date:  2010-11-15       Impact factor: 7.446

6.  Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes.

Authors:  Pavel Štarha; Ján Vančo; Zdeněk Trávníček; Jan Hošek; Jarmila Klusáková; Zdeněk Dvořák
Journal:  PLoS One       Date:  2016-12-01       Impact factor: 3.240

7.  N-Heterocyclic Carbene Platinum(IV) as Metallodrug Candidates: Synthesis and 195Pt NMR Chemical Shift Trend.

Authors:  Mathilde Bouché; Bruno Vincent; Thierry Achard; Stéphane Bellemin-Laponnaz
Journal:  Molecules       Date:  2020-07-09       Impact factor: 4.411

8.  In Cellulo Evaluation of the Therapeutic Potential of NHC Platinum Compounds in Metastatic Cutaneous Melanoma.

Authors:  Elsa Charignon; Mathilde Bouché; Caroline Clave-Darcissac; Georges Dahm; Gabriel Ichim; Anthony Clotagatide; Hichem C Mertani; Philippe Telouk; Julie Caramel; Jean-Jacques Diaz; Stéphane Bellemin-Laponnaz; Philippe Bouvet; Claire Billotey
Journal:  Int J Mol Sci       Date:  2020-10-22       Impact factor: 5.923
  8 in total

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