Literature DB >> 201470

Effect of chlorpropamide and phenformin on rat liver: the effect on plasma membrane-bound enzymes and cyclic AMP content of hepatocytes in vitro.

P Luly, P Baldini, C Cocco, S Incerpi, E Tria.   

Abstract

Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-bound adenylate cyclase. The results suggest that the plasma membrane plays an important role in the mechanism of action of the two hypoglycemic drugs, but do not exclude the presence of intracellular targets.

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Year:  1977        PMID： 201470     DOI： 10.1016/0014-2999(77)90251-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  3 in total

Review 1.  The role of AMPK in regulation of Na+,K+-ATPase in skeletal muscle: does the gauge always plug the sink?

Authors:  Sergej Pirkmajer; Metka Petrič; Alexander V Chibalin
Journal:  J Muscle Res Cell Motil       Date:  2021-01-04       Impact factor: 2.698

2.  Phenformin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells.

Authors:  Alison M Woollhead; John W Scott; D Grahame Hardie; Deborah L Baines
Journal:  J Physiol       Date:  2005-05-26       Impact factor: 5.182

3.  Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

Authors:  A M Woollhead; J Sivagnanasundaram; K K Kalsi; V Pucovsky; L J Pellatt; J W Scott; K J Mustard; D G Hardie; D L Baines
Journal:  Br J Pharmacol       Date:  2007-07-02       Impact factor: 8.739
  3 in total

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