| Literature DB >> 2014651 |
C A Mauracher1, S Gillam, R Shukin, A J Tingle.
Abstract
The mechanism of capsid uncoating in rubella virus and other togaviridae is not well understood. This study presents data which suggest that rubella virus capsid undergoes a structural change from having hydrophilic to hydrophobic properties, between pH 5 and 5.5. Such a conformational change would allow capsid uncoating to occur within the lysosome, allowing RNA penetration to occur upon fusion of the viral envelope with the limiting membrane of the lysosome.Entities:
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Year: 1991 PMID： 2014651 DOI： 10.1016/0042-6822(91)90916-y
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616