Literature DB >> 20145088

Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

Gengrong Lin1, Lois M Ednie, Peter C Appelbaum.   

Abstract

Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.

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Year:  2010        PMID： 20145088      PMCID： PMC2863652          DOI： 10.1128/AAC.01350-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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