Literature DB >> 20141517

Dealing with hERG liabilities early: diverse approaches to an important goal in drug development.

B D Guth1, G Rast.   

Abstract

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Year:  2010        PMID： 20141517      PMCID： PMC2823348          DOI： 10.1111/j.1476-5381.2009.00265.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


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  1 in total

Review 1.  An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk.

Authors:  Chris E Pollard; N Abi Gerges; M H Bridgland-Taylor; A Easter; T G Hammond; J-P Valentin
Journal:  Br J Pharmacol       Date:  2010-01       Impact factor: 8.739
  1 in total
  11 in total

1.  Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

Authors:  Yama A Abassi; Biao Xi; Nan Li; Wei Ouyang; Alexander Seiler; Manfred Watzele; Ralf Kettenhofen; Heribert Bohlen; Andreas Ehlich; Eugen Kolossov; Xiaobo Wang; Xiao Xu
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

2.  GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2.

Authors:  Justin R Nickell; Kiran B Siripurapu; David B Horton; Guangrong Zheng; Peter A Crooks; Linda P Dwoskin
Journal:  Eur J Pharmacol       Date:  2016-12-13       Impact factor: 4.432

3.  Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer Cells.

Authors:  Vitaliy M Sviripa; Liliia M Kril; Wen Zhang; Yanqi Xie; Przemyslaw Wyrebek; Larissa Ponomareva; Xifu Liu; Yaxia Yuan; Chang-Guo Zhan; David S Watt; Chunming Liu
Journal:  Medchemcomm       Date:  2017-11-03       Impact factor: 3.597

Review 4.  An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk.

Authors:  Chris E Pollard; N Abi Gerges; M H Bridgland-Taylor; A Easter; T G Hammond; J-P Valentin
Journal:  Br J Pharmacol       Date:  2010-01       Impact factor: 8.739

5.  Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.

Authors:  Sanjib K Shrestha; Liliia M Kril; Keith D Green; Stefan Kwiatkowski; Vitaliy M Sviripa; Justin R Nickell; Linda P Dwoskin; David S Watt; Sylvie Garneau-Tsodikova
Journal:  Bioorg Med Chem       Date:  2016-10-10       Impact factor: 3.641

6.  Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.

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Journal:  Org Biomol Chem       Date:  2016-01-07       Impact factor: 3.876

8.  From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter.

Authors:  Barbara Zdrazil; Eva Hellsberg; Michael Viereck; Gerhard F Ecker
Journal:  Medchemcomm       Date:  2016-07-22       Impact factor: 5.121

9.  A structure-based computational workflow to predict liability and binding modes of small molecules to hERG.

Authors:  Subha Kalyaanamoorthy; Shawn M Lamothe; Xiaoqing Hou; Tae Chul Moon; Harley T Kurata; Michael Houghton; Khaled H Barakat
Journal:  Sci Rep       Date:  2020-10-01       Impact factor: 4.379

10.  Druggability of Coronary Artery Disease Risk Loci.

Authors:  Vinicius Tragante; Daiane Hemerich; Mohammad Alshabeeb; Ingrid Brænne; Harri Lempiäinen; Riyaz S Patel; Hester M den Ruijter; Michael R Barnes; Jason H Moore; Heribert Schunkert; Jeanette Erdmann; Folkert W Asselbergs
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