Literature DB >> 20141162

Reactions of oxetan-3-tert-butylsulfinimine for the preparation of substituted 3-aminooxetanes.

Philip J Hamzik1, Jason D Brubaker.   

Abstract

The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine is described.

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Year:  2010        PMID： 20141162     DOI： 10.1021/ol100119e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Gold-catalyzed one-step practical synthesis of oxetan-3-ones from readily available propargylic alcohols.

Authors:  Longwu Ye; Weimin He; Liming Zhang
Journal:  J Am Chem Soc       Date:  2010-06-30       Impact factor: 15.419

2.  Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides.

Authors:  Juan J Rojas; Rosemary A Croft; Alistair J Sterling; Edward L Briggs; Daniele Antermite; Daniel C Schmitt; Luka Blagojevic; Peter Haycock; Andrew J P White; Fernanda Duarte; Chulho Choi; James J Mousseau; James A Bull
Journal:  Nat Chem       Date:  2022-01-27       Impact factor: 24.274

3.  Structure property relationships of N-acylsulfonamides and related bioisosteres.

Authors:  Karol R Francisco; Carmine Varricchio; Thomas J Paniak; Marisa C Kozlowski; Andrea Brancale; Carlo Ballatore
Journal:  Eur J Med Chem       Date:  2021-03-28       Impact factor: 7.088

4.  Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.

Authors:  Martin McLaughlin; Ryo Yazaki; Thomas C Fessard; Erick M Carreira
Journal:  Org Lett       Date:  2014-07-28       Impact factor: 6.005
  4 in total

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